N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide

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更新时间： 2022-02-12 17:28:31

CAS号：362003-83-6

常用名： NVP-231

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： NVP-231 is a potent, specific, and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits binding of ceramide to CerK.IC50 Value: 12±2 nM [1]Target: CERKin vitro: NVP-231 showed an IC50 value of 12 ± 2 nM and 90% inhibition at 100 nM in the radioassay. NVP-231 did not compete with ATP but rather with ceramide, displaying an inhibition constant (Ki) of 7.4 nM. Furthermore, inhibition by NVP-231 was instantaneous and fully reversible, implying that this compound does not covalently modify CerK. At 10 nM, NVP-231 inhibited C1P formation by >50%; at 100 nM, NVP-231 achieved complete inhibition. Thus the potency and efficacy of NVP-231 observed in cell culture are consistent with those found in vitro. It is noteworthy that, NVP-231 did not inhibit GlcCer and SM formation; rather, it increased these metabolites in correlation with compound concentration, demonstrating that NVP-231 does not act as a general inhibitor of ceramide metabolism [1]. The EC(50) of NVP-231 in this assay is in the low nanomolar range, consistent with the IC(50) determined in activity assays in vitro using purified CerK [2]. 物理化学性质： CAS号：362003-83-6 常用中文名：NVP-231 常用英文名：NVP 231 分子式：C25H25N3O2S 分子量：431.550 密度：1.4±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2~8°C，密封

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

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2024-03-12 价格：￥2162.9 NVP-231

2024-07-15 价格：需询单 NVP-231

2021-02-06 价格：￥3029.0 NVP 231

2023-09-15 价格：￥需询单 NVP231

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NVP-231价格

N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide

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