Azilsartan medoxomil

产品详情：

更新时间： 2022-01-28 17:01:08

CAS号：863031-21-4

常用名： 阿齐沙坦奥美沙坦酯

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. IC50 Value: 0.62 nM [2]Target: AT1 receptorin vitro: In aortic endothelial cells, azilsartan inhibited cell proliferation at concentrations as low as 1 μmol/l, whereas valsartan showed little or no antiproliferative effects at concentrations below 10 μmol/l. Antiproliferative effects of azilsartan were also observed in cells lacking AT1 receptors[1].in vivo: Oral administration of 0.1-3 mg/kg olmesartan medoxomil reduced blood pressure; however, only the two highest doses significantly reduced blood pressure 24h after dosing. ED(25) values were 0.41 and 1.3 mg/kg for azilsartan medoxomil and olmesartan medoxomil, respectively [2]. Over a longer treatment period of 24 weeks, azilsartan medoxomil showed sustained BP-lowering efficacy, with the reduction in 24-hour mean SBP at week 24 significantly greater with azilsartan medoxomil 40 or 80 mg once daily than with valsartan 320 mg once daily. Mean reductions from baseline in mean clinic SBP and DBP as well as DBP by ABPM were also significantly greater with azilsartan medoxomil 40 or 80 mg once daily than with valsartan[3]. In 4 randomized controlled trials (3 published to date), azilsartan medoxomil/chlorthalidone 40 mg/12.5 mg and 40 mg/25 mg reduced blood pressure (BP) significantly more than comparators did, including an approximately 5-mm Hg greater BP reduction than olmesartan medoxomil/hydrochlorothiazide 40 mg/25 mg and azilsartan medoxomil/hydrochlorothiazide [4].Clinical trial: Effect of Azilsartan on Aldosterone in Post-menopausal Females . Phase not specified 物理化学性质： CAS号：863031-21-4 常用中文名：阿齐沙坦奥美沙坦酯常用英文名：Azilsartan medoxomil 分子式：C30H24N4O8 分子量：568.534 密度：1.5±0.1 g/cm3 沸点：748.0±70.0 °C at 760 mmHg 熔点：N/A 闪点：406.2±35.7 °C 储存条件：-20℃

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

电话： +86571-88938639

地址： 浙江省杭州市西湖区文三路259号2栋9楼

地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

网址：http://www.dycnchem.com

主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

主要合作伙伴：

公司介绍：

其他供应商价格：

2022-11-29 价格：￥需询单 Azilsartan medoxomil

2025-09-17 价格：￥需询单阿齐沙坦奥美沙坦酯

2022-03-04 价格：￥121.9 Azilsartan Medoxomil

2023-04-24 价格：￥需询单阿奇沙坦酯

2017-07-07 价格：￥需询单阿齐沙坦酯

2018-04-22 价格：￥需询单 1-[[2’-(2,5-二氢-5-氧代-1,2,4-恶二唑-3-基)[1,1’-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸 (5-甲基-2-氧代-1,3-二恶茂-4-基)甲酯

2021-02-06 价格：￥1489.0 Azilsartan Medoxomil

2018-10-26 价格：￥需询单阿齐沙坦酯 863031-21-4

2017-09-30 价格：￥需询单 1-[[2'-(2,5-二氢-5-氧代-1,2,4-恶二唑-3-基)[1,1'-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸 (5-甲基-2-氧代-1,3-二恶茂-4-基)甲酯

2024-01-09 价格：$需询单 Azilsartan Medoxomil

查看所有价格请点击：

阿齐沙坦奥美沙坦酯价格

Azilsartan medoxomil

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：