Arenobufagin

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更新时间： 2023-10-04 23:02:17

CAS号：464-74-4

常用名： 沙蟾蜍精

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.IC50 value: Target: in vitro: arenobufagin induced mitochondria-mediated apoptosis in HCC cells, with decreasing mitochondrial potential, as well as increasing Bax/Bcl-2 expression ratio, Bax translocation from cytosol to mitochondria. Arenobufagin also induced autophagy in HepG2/ADM cells. Autophagy-specific inhibitors (3-methyladenine, chloroquine and bafilomycin A1) or Beclin1 and Atg 5 small interfering RNAs (siRNAs) enhanced arenobufagin-induced apoptosis, indicating that arenobufagin-mediated autophagy may protect HepG2/ADM cells from undergoing apoptotic cell death [1]. arenobufagin inhibited vascular endothelial growth factor (VEGF)-induced viability, migration, invasion and tube formation in human umbilical vein endothelial cells (HUVECs) in vitro [2]. Arenobufagin blocked the Na+/K+ pump current in a dose-dependent manner with a half-maximal concentration of 0.29 microM and a Hill coefficient of 1.1 [3].in vivo: arenobufagin inhibited the growth of HepG2/ADM xenograft tumors, which were associated with poly (ADP-ribose) polymerase cleavage, light chain 3-II activation and mTOR inhibition [1]. Arenobufagin also suppressed sprouting formation from VEGF-treated aortic rings in an ex vivo model [2]. 物理化学性质： CAS号：464-74-4 常用中文名：沙蟾蜍精常用英文名：Arenobufagin 分子式：C24H32O6 分子量：416.507 密度：1.4±0.1 g/cm3 沸点：637.2±55.0 °C at 760 mmHg 熔点：N/A 闪点：219.3±25.0 °C 储存条件：-20°C

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 48306件

电话： +86571-88938639

地址： 浙江省杭州市西湖区文三路259号2栋9楼

地区： 杭州市西湖区

联系人： 王小姐

联系人电话： +86-571-8893-8639

邮件：enquiry@dycnchem.com

网址：http://www.dycnchem.com

主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2026-01-15 价格：￥200.0 沙蟾毒精

2024-09-29 价格：￥需询单沙蟾毒精

2025-12-29 价格：￥需询单沙蟾毒精

2019-03-05 价格：￥1568.0 沙蟾毒精

2024-07-15 价格：需询单沙蟾毒精

2021-04-03 价格：￥762.0 Arenobufagin

2022-10-11 价格：￥750.0 沙蟾蜍精，沙蟾毒精Arenobufagin

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沙蟾蜍精价格

Arenobufagin

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