PNU-282987

产品详情：

发布时间： 2021-07-26 18:31:54

CAS号：123464-89-1

常用名： PNU-282987

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).IC50 value: 26 nM(Ki) [1]Target: α7 nAChR agonistin vitro: Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion [3].in vivo: Mice were subjected to 70% partial hepatic I/R for 60 min and pretreated with either vehicle or with PNU-282987, and blood and hepatic tissue samples were collected at 3, 6, and 12 h following reperfusion. pretreatment with PNU-282987 decreased serum transaminase levels and ameliorated liver injury after hepatic I/R. Moreover, pretreatment with PNU-282987 suppressed NF-κB activation, cytokine production (tumor necrosis factor α, interleukin 1β), and HMGB1 expression in liver after hepatic I/R [2]. Mice treated with 2.5 and 10 mg/kg of PNU devoted less time to rearing into open arms. In the HB task, MC mice displayed higher exploratory activity reflected in more head-dips (HD) during the first minute than EE and SE, whereas EE displayed low exploration levels reflected in total HD (5 min) [4]. 物理化学性质： CAS号：123464-89-1 常用中文名：PNU-282987 常用英文名：PNU 282987 分子式：C14H18Cl2N2O 分子量：301.21 密度：1.3±0.1 g/cm3 沸点：431.5±30.0 °C at 760 mmHg 熔点：N/A 闪点：214.8±24.6 °C 储存条件：2-8℃

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

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地区： 杭州市西湖区

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联系人电话： +86-571-8893-8639

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主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2022-03-04 价格：￥113.9 PNU 282987

2023-09-11 价格：￥需询单 PNU282987

2021-02-06 价格：￥2689.0 PNU 282987

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PNU-282987价格

PNU-282987

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