Pentamidine

产品详情：

发布时间： 2021-07-26 18:31:53

CAS号：100-33-4

常用名： 喷他脒

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Pentamidine(MP-601205) is an antimicrobial agent.Target: AntiparasiticPentamidine has a potent in vitro antiprotozoal activity. Pentamidine displays cytotoxic activity against L. infantum promastigotes with IC50 of 2.5 μM. 2.5 μM Pentamidine induces early programmed cell death in 49.6% of L. infantum promastigotes. 2.5 μM Pentamidine induces a notorious decrease in promastigotes in both G1 and S phases relative to the control-untreated samples (G1:77.0 vs 15.0%; S:11.0 vs 2.4% for control- and pentamidine-treated promastigotes, resp). Pentamidine is able to bind with calf-thymus DNA (CT-DNA) and induces conformational changes in the DNA double helix. Pentamidine also binds with ubiquitin to modifiy the β-cluster of ubiquitin [1]. Pentamidine is an inhibitor of phosphatase of regenerating liver (PRLs). 1 μg/mL of Pentamidine complete inhibits the activity of recombinant PTP1B in dephosphorylating a phos-photyrosine peptide. 10 μg/mL of Pentamidine completely inhibits the activities of recombinant PRL-1, PRL-2 and PRL-3 in dephosphorylating a phosphotyrosine peptide substrate. Incubation with Pentamidine (1 μg/mL) for 48 h reduces the activity of intracellular PRL phosphatases in transfected NIH3T3 cells by more than 85%. 10 μg/mL Pentamidine completely inhibits the growth of melanoma cell line (WM9), prostate carcinoma cell line (DU145 and C4-2), ovarian carcinoma cell line (Hey), colon carcinoma cell line (WM480), and lung carcinoma cell line (A549) which all express endogenous PRLs [2]. 作用：本品作用机制尚不够清楚，可能干扰核苷酸生物合成和DNA的复制，也可干扰叶酸盐的转换。物理化学性质： CAS号：100-33-4 常用中文名：喷他脒常用英文名：Pentamidine 分子式：C19H24N4O2 分子量：340.419 密度：1.2±0.1 g/cm3 沸点：539.4±60.0 °C at 760 mmHg 熔点：186ºC (dec.) 闪点：280.0±32.9 °C 储存条件：-20°C Freezer, Under Inert Atmosphere

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

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主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2022-03-04 价格：￥3385.0 喷他脒

2024-07-15 价格：需询单 4,4''-二脒基二苯氧基戊烷

2019-03-05 价格：￥1426.0 喷他脒碱

2021-02-06 价格：￥509.0 Pentamidine

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喷他脒价格

Pentamidine

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