(S)-2-nitro-6-((6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)Methoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

产品详情：

发布时间： 2021-07-26 18:31:22

CAS号：1257426-19-9

常用名： TBA-354

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.IC50 value:Target: Anti-tuberculosis agentin vitro: TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates [1]. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy [2].in vivo: TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824. 物理化学性质： CAS号：1257426-19-9 常用中文名：TBA-354 常用英文名：TBA-354 分子式：C19H15F3N4O5 分子量：436.341 密度：1.5±0.1 g/cm3 沸点：570.0±60.0 °C at 760 mmHg 熔点：N/A 闪点：298.5±32.9 °C 储存条件：2-8℃

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

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2025-02-05 价格：￥3325.9 TBA-354

2024-07-15 价格：需询单 TBA-354

2023-09-14 价格：￥需询单 TBA354

2021-02-06 价格：￥4889.0 TBA354

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TBA-354价格

(S)-2-nitro-6-((6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)Methoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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