1-(2-(BENZHYDRYLOXY)ETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE MALEATE

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更新时间： 2025-12-29 11:05:18

CAS号：76778-22-8

常用名： GBR 12935

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： GBR 12935 is a potent, and selective dopamine reuptake inhibitor.IC50 value: Target: dopamine reuptake inhibitorin vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6. The binding of [3H]GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine) [1]. Co-perfusion of 100 microM GBR 12909 or GBR 12935 with either 100 microM sulpiride or raclopride produced a significant reduction in the GBR 12909 or GBR 12935 induced increase in the extracellular levels of dopamine to basal levels. In vitro, GBR 12909 (1-9 nM) dose-dependently inhibited active uptake of [3H]dopamine in homogenates of the nucleus accumbens [2].in vivo: GBR 12935 elevated locomotion to a greater extent in C57BL/6J mice at the maximally active dose of 10 mg/kg. Locomotor stimulation by GBR 12935 remained consistent in both strains with repeated injections. DBA/2J mice became sensitized to cocaine-induced stereotypy with repeated injections. Cocaine induced no stereotypy in C57BL/6J mice on any test day. No stereotypies were induced by GBR 12935 in either strain on any test day [3]. 物理化学性质： CAS号：76778-22-8 常用中文名：GBR 12935 常用英文名：GBR 12935 分子式：C28H34N2O 分子量：414.58 密度：1.067g/cm3 沸点：540.6ºC at 760 mmHg 熔点：N/A 闪点：143.9ºC 储存条件：2-8℃

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

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其他供应商价格：

2024-07-15 价格：需询单 GBR-12935

2021-05-10 价格：￥需询单 (DIPHENYLMETHOXY)GBR - 12935,1 - (2 - 乙基)-4 - (3 - 苯丙基)哌嗪

2017-08-06 价格：￥需询单 GBR 12935

2017-08-04 价格：￥需询单 1 - （2 - 乙基）-4 - （3 - 苯丙基）哌嗪, 马来酸盐

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GBR 12935价格

1-(2-(BENZHYDRYLOXY)ETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE MALEATE

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