Iloperidone

产品详情：

发布时间： 2021-07-26 18:31:53

CAS号：133454-47-4

常用名： 伊潘立酮

价格：
$需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： Iloperidone(HP 873) is a D2/5-HT2 receptor antagonist, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.IC50 value:Target: 5-HT receptor; D2 receptorIloperidone (HP 873) is a compound currently in clinical trials for the treatment of schizophrenia. Iloperidone displays affinity for dopamine D2 receptors and for 5-HT2A receptors and has a variety of in vivo activities suggestive of an atypical antipsychotic. Iloperidone displayed higher affinity for the dopamine D3 receptor (Ki = 7.1 nM) than for the dopamine D4 receptor (Ki = 25 nM). Iloperidone displayed high affinity for the 5-HT6 and 5-HT7 receptors (Ki = 42.7 and 21.6 nM, respectively), and was found to have higher affinity for the 5-HT2A (Ki = 5.6 nM) than for the 5-HT2C receptor (Ki = 42.8 nM) [1]. Iloperidone was eliminated slowly, with a mean t1/2 of 13.5 to 14.0 hours. Coadministration with food did not significantly affect AUC, tmax, or Cmax. These results indicate that the rate of iloperidone's absorption is decreased, but the overall bioavailability is unchanged, when the drug is taken with food. Orthostatic hypotension, dizziness, and somnolence were the most commonly reported adverse events [2]. Iloperidone pharmacokinetics and pharmacodynamics are presented herein, together with an evaluation of clinical safety and efficacy results [3].Clinical indications: Post traumatic stress disorder; Schizophrenia Toxicity: Commonly observed adverse reactions (incidence ≥5% and two-fold greater than placebo) were: dizziness, dry mouth, fatigue, nasal congestion, orthostatic hypotension, somnolence, tachycardia, and weight increased. 物理化学性质： CAS号：133454-47-4 常用中文名：伊潘立酮常用英文名：Iloperidone 分子式：C24H27FN2O4 分子量：426.481 密度：1.2±0.1 g/cm3 沸点：593.7±50.0 °C at 760 mmHg 熔点：118-120°C 闪点：312.8±30.1 °C 储存条件：-20°C Freezer, Under Inert Atmosphere

供应商信息：

公司名：达阳化工（杭州）有限公司推荐

认证状态： 已认证供应商

商品数： 50181件

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主要市场：Mainly in Southeast Asia and European and American markets

年贸易额：10 to 20 million USD

外贸占销售比例：90%

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其他供应商价格：

2024-07-15 价格：需询单 Iloperidone

2022-11-29 价格：￥需询单 Iloperidone (Fanapt)

2021-02-06 价格：￥639.0 Iloperidone

2022-02-19 价格：￥525.9 伊潘立酮

2023-11-18 价格：￥需询单 ILOPERIDONE

2017-08-06 价格：￥需询单伊潘立酮

2017-06-13 价格：￥需询单伊潘立酮

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伊潘立酮价格

Iloperidone

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