1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
产品详情：
更新时间： 2024-01-28 22:38:08
CAS号：570406-98-3
常用名：
价格：
$需询单/100g
$需询单/1kg
$需询单/10kg
$需询单/25kg
纯度： 98.0%
备货期： 需询单
库存： 询单
其他详情（用途，包装）：
用途： Avatrombopag(AKR-501; AS1670542) is a novel orally-active thrombopoietin(TPO) receptor agonist with EC50 of 3.3 nM.EC50 value: 3.3 nM [1]Target: TPO receptor agonistin vitro: AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501, however, was shown to be effective only in humans and chimpanzees with high species specificity [1]. AS1670542 has 50% effective concentration values for cell proliferation with AS1670542 or eltrombopag were 1.9 and 13nM, respectively, while those for megakaryocyte colony formation from human cord blood CD34(+) cells with AS1670542 or eltrombopag were 260 and 950nM, respectively [2].in vivo: Daily oral administration of AKR-501 dose-dependently increased the number of human platelets in in human platelet producing non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice transplanted with human fetal liver CD34(+) cells, with significance achieved at doses of 1 mg/kg and above. The peak unbound plasma concentrations of AKR-501 after administration at 1 mg/kg in NOD/SCID mice were similar to those observed following administration of an active oral dose in human subjects [1]. AS1670542 significantly increased the number of human platelets in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice with transplanted human hematopoietic stem cells at 0.3 (P 物理化学性质： CAS号：570406-98-3 常用中文名：马来酸阿伐曲波帕 常用英文名：avatrombopag 分子式：C29H34Cl2N6O3S2 分子量：649.655 密度：1.4±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃
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公司名：Changzhou Guiding Bio-Tech. Co.,Ltd.
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商品数： 397件
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地址： 太湖东路9号创意产业园4栋622室
地区： 常州市新北区
联系人： Liya Liu
联系人电话： +8618602580039
邮件：lly@guiding-bio.com
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公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥482.9/10mg
￥1511.9/50mg
￥308.9/5mg
￥9880.9/1g
联系人：阿拉丁
产品详情：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
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其他供应商价格：
2024-03-12 价格：￥482.9
2024-07-15 价格：需询单
2017-10-27 价格：￥需询单
2021-04-03 价格：￥3416.0
2022-04-24 价格：￥需询单
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相关产品价格：
1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid价格为$需询单/100g, 由1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid生产厂家Changzhou Guiding Bio-Tech. Co.,Ltd.提供，供应信息包括纯度，备货期/库存，供货能力等。>>电脑版：1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid_价格_生产厂家【Changzhou Guiding Bio-Tech. Co.,Ltd.】
标题：1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid - 生产厂家：Changzhou Guiding Bio-Tech. Co.,Ltd. 地址：https://m.chemsrc.com/mip/chanpin/4932943.html