Moclobemide (Ro 111163)

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更新时间： 2025-09-01 19:29:57

CAS号：71320-77-9

常用名： 吗氯贝胺

价格：
￥需询单/1g ￥需询单/5g

纯度： 98.0%

备货期： 需询单

库存： 现货

其他详情（用途，包装）：
用途： Moclobemide(Ro111163) is a reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.Target: Monoamine OxidaseMoclobemide orally administered 2 hours before decapitation preferentially inhibits MAO-A and PEA in rat brain with ED50 of 7.6 μmol/kg and 78 μmol/kg, respectively. Moclobemide orally administered 2 hours before decapitation preferentially inhibits MAO-A and PEA in rat liver with ED50 of 8.4 μmol/kg and 6.6 μmol/kg, respectively. Moclobemide (0.1 mM), which inhibits brain MAO-A activity by over 80%, does not affect benzylamine oxidase (rat heart) and diamine oxidase (rat small intestine) activity in vitro [1]. Moclobemide (10 mM-100 mM) includes in the culture medium during anoxia or with glutamate significantly increases in a concentration-dependent manner the amount of surviving neurons compared to controls in neuronal-astroglial cultures from rat cerebral cortex [2].Moclobemide (10 mg/kg p.o.) induces a significant decrease of all monoamine metabolites measured in rat brain [1]. Moclobemide, given via the drinking water (4.5 mg/kg/day), produces significant decreases in adrenal weight of rats after 5 (-23%) and 7 weeks (-16%) of treatment. Moclobemide upregulates hippocampal mineralocorticoid receptor (MR) levels in rats by 65%, 76% and 19% at 2 weeks, 5 weeks and 7 weeks of treatment, and upregulates Glucocorticoid receptor (GR) levels in this limbic brain structure by 10% at 5 weeks. Moclobemide treatment (5 weeks, 4.5 mg/kg/day) significantly attenuates stress (30 min novel environment)-induced plasma ACTH (-35%) and corticosterone (-29%) levels [3]. 物理化学性质： CAS号：71320-77-9 常用中文名：吗氯贝胺常用英文名：Moclobemide 分子式：C13H17ClN2O2 分子量：268.739 密度：1.2±0.1 g/cm3 沸点：447.7±40.0 °C at 760 mmHg 熔点：137°C 闪点：224.6±27.3 °C 储存条件：Room temp

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2022-02-19 价格：￥289.9 吗氯贝胺

2025-09-17 价格：￥需询单吗氯贝胺

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2024-07-15 价格：需询单吗氯贝胺

2017-12-04 价格：￥需询单吗氯贝胺

2018-07-11 价格：￥需询单吗氯贝胺

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Moclobemide (Ro 111163)

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