CMX 001

产品详情：

更新时间： 2024-01-10 21:23:03

CAS号：444805-28-1

常用名： Brincidofovir

价格：
￥需询单/1g ￥需询单/5g

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： CMX001 (Brincidofovir; HDP-CDV) was developed as an orally active, lipophilic form of cidofovir (CDV); has enhanced activity in vitro and in vivo compared to CDV against certain herpesviruses, adenoviruses and orthopoxviruses.IC50 Value: 5.5 nM (EC50, in PDA at 7 dpi) [3]Target: anti-CMVCMX001 is currently in Phase II clinical studies for development as a therapeutic agent for human CMV, adenovirus and BK virus infections, as well as, for adverse events following smallpox vaccinations.in vitro: In PDA at 7 dpi, the CMX001 50% effective concentration (EC50) was 5.55 nM, the 50% cytotoxic concentration (CC50) was 184.6 nM, and the 50% selectivity index (SI50) was 33.3. The EC90 was 19.7 nM, the CC90 was 5,054 nM, and the SI90 was 256.1. In COS-7 cells, JCV replication was faster and the EC50 and EC90 were 18- and 37-fold higher than those in PDA, i.e., 0.1 μM and 0.74 μM (CC50, 0.67 μM; SI50, 6.7; CC90, 12.2 μM; SI90, 16.5) at 5 dpi [3].in vivo: CMX001 and CDV are equally efficacious at protecting mice from mortality following high ectromelia virus doses (10,000 x LD(50)) introduced by the intra-nasal route or small particle aerosol. Using CMX001 at a 10mg/kg dose followed by 2.5mg/kg doses every other-day for 14 days provided solid protection against mortality and weight loss following an intra-nasal challenge of (100-200) x LD(50) of ectromelia virus [1]. When CMX001 was administered orally to mice infected with HSV-1, mortality was reduced significantly (p≤0.001) with all three dose levels when treatments were initiated 24 h post viral inoculation. When treatments were started 48 h post viral inoculation, 5 and 2.5 mg/kg significantly reduced mortality (p≤ 0.001). If treatments were delayed until 72 h post viral inoculation, CMX001 did not reduce mortality or increase the mean day to death. When mice were infected intranasally with HSV-1 and treatments initiated 24 h post viral inoculation using CMX001 at 5 mg/kg or ACV at 100 mg/kg, virus replication in target organs was reduced by both CMX001 and ACV when compared to vehicle treated mice [2]. Toxicity: Diarrhea was the most common adverse event in patients receiving CMX001 at doses of 200 mg weekly or higher and was dose-limiting at 200 mg twice weekly. Myelosuppression and nephrotoxicity were not observed [4]. 物理化学性质： CAS号：444805-28-1 常用中文名：Brincidofovir 常用英文名：Brincidofovir 分子式：C27H52N3O7P 分子量：561.69100 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20°C，密闭，干燥

供应商信息：

公司名：武汉敬康恩生物医药科技有限公司推荐

认证状态： 已认证供应商

商品数： 5262件

电话： 15871494362

地址： 光谷大道58号

地区： 武汉市东西湖区

联系人： 周经理

联系人电话： 15871494362

邮件：orders@jknbiochem.com

网址：http://www.jknbiochem.com

其他供应商价格：

2024-07-15 价格：需询单 CMX001

2022-11-29 价格：￥需询单 Brincidofovir (CMX-001)

2021-02-06 价格：￥17989.0 CMX001

2021-12-23 价格：￥8131.0 [Perfemiker]Brincidofovir (CMX-001),98%

2023-09-22 价格：￥需询单 Brincidofovir

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Brincidofovir价格

CMX 001

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