特泊替尼

产品详情：

更新时间： 2024-03-09 17:27:21

CAS号：1100598-32-0

常用名： 特泊替尼

价格：
￥1.0/1kg

纯度： 98.0%

备货期： 1天

库存： 现货

其他详情（用途，包装）：
用途： EMD 1214063 is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. IC50 Value: 4 nM [1]Target: c-Metin vitro: EMD 1214063 inhibits HGF-induced c-Met phosphorylation in A549 cells with IC50 of 6 nM. Treatment with EMD 1214063 induces a marked reduction of c-Met–constitutive phosphorylation in EBC-1 cells with IC50 of 9 nM. EMD 1214063 effectively blocka phosphorylation of the major downstream effectors of the c-Met enzyme, such as Grb2, Gab1, Sos, PLCγ, and phosphoinositide 3-kinase, in EBC-1, MKN-45, and Hs746T cells in the range of 1 to 10 nM. EMD 1214063 considerably inhibits the viability of MKN-45 cells with IC50 of less than 1 nM. Treatment with EMD 1214063 (as low as 0.1 nM) inhibits HGF-induced NCI-H441 cell migration, whereas concentrations of 100 nM to 1 μM almost completely prevents it.in vivo: EMD 1214063 treatment, at doses of 10 mg/kg or more, results in more than 90% inhibition of c-Met phosphorylation in Hs746T xenograft tumor for a period of at least 72 hours. EMD 1214063 induces more than 50% reduction of cyclin D1 expression, which persists after 96 hours upon treatment with doses of 100 mg/kg. A transient induction of p27 and cleaved caspase-3 are also observed upon treatment with EMD 1214063. EMD 1214063 (15 mg/kg, daily) treatment induces complete regression of gastric carcinoma xenografts Hs746T, in which c-Met is amplified, overexpressed, and activated in a ligand-independent fashion. 物理化学性质： CAS号：1100598-32-0 常用中文名：特泊替尼常用英文名：tepotinib 分子式：C29H28N6O2 分子量：492.572 密度：1.3±0.1 g/cm3 沸点：626.5±65.0 °C at 760 mmHg 熔点：N/A 闪点：332.7±34.3 °C 储存条件：-20℃

供应商信息：

公司名： 武汉敬康恩生物医药科技有限公司推荐

认证状态： 已认证供应商

商品数： 4835件

电话： 15871494362

地址： 光谷大道58号

地区： 武汉市东西湖区

联系人： 周经理

联系人电话： 15871494362

邮件：orders@jknbiochem.com

网址：http://www.jknbiochem.com

其他供应商价格：

2020-12-08 价格：￥807.5特泊替尼（EMD 1214063）

2021-12-23 价格：￥1130.0[Perfemiker]Tepotinib,99%

2022-03-04 价格：￥5199.9特泊替尼

2017-02-10 价格：￥800.03-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile

2022-05-12 价格：$需询单Tepotinib(EMD-1214063)

2018-04-15 价格：￥需询单EMD1214063

2023-08-30 价格：￥需询单EMD1214063

2016-06-17 价格：￥需询单3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile

2023-11-13 价格：￥需询单特泊替尼

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特泊替尼

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