SGC707

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更新时间： 2025-09-08 19:03:12

CAS号：1687736-54-4

常用名： SGC707

价格：
￥需询单/1kg ￥需询单/1g ￥需询单/1mg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： SGC707 is a first-in-class PRMT3 chemical probe which is a potent, selective, and cell-active allosteric inhibitor of PRMT3 with IC50 of 31 nM.IC50 value: 31 nMTarget: PRMT3in vitro: SGC707 is the first PRMT3 chemical probe. SGC707 is a potent PRMT3 inhibitor (IC50=31±2 nM, KD=53±2 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets). SGC707 can engage PRMT3 and effectively inhibit its catalytic activity in cells and that overexpressed PRMT3 can methylate histone H4 in cells. SGC707 stabilizes PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM in PRMT3 InCELL Hunter Assays.in vivo: SGC707 is bioavailable and suitable for animal studies. This well characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease. We assessed in vivo pharmacokinetic (PK) properties of SGC707. Intraperitoneal injection of SGC707 at 30 mg/kg gave good plasma exposure in CD-1 male mice over 6 h with the peak plasma level of 38000 nM. The plasma level of SGC707 at 6 h post injection was 208 nM, more than 2-fold higher than its IC50 value in the cellular assay and the half-life of SGC707 was about 1 h. This mdose was well tolerated by the test animals. These results suggest that SGC707 is suitable for animal studies in addition to cell-based studies. 物理化学性质： CAS号：1687736-54-4 常用中文名：SGC707 常用英文名：SGC707 分子式：C16H18N4O2 分子量：298.340 密度：1.3±0.1 g/cm3 沸点：538.5±46.0 °C at 760 mmHg 熔点：N/A 闪点：279.5±29.0 °C 储存条件：-20℃

供应商信息：

公司名：上海楼岚生物科技有限公司

认证状态： 未认证供应商

商品数： 2474件

电话： 52996696

地址： 沪南路2729弄1310号

地区： 上海市浦东新区

联系人： 孙先生

联系人电话： 021-52996696

邮件：sales@lollanechem.com

网址：http://www.bioll.com

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2024-03-12 价格：￥679.9 SGC707

2019-03-05 价格：￥586.0 1-(异喹啉-6-基)-3-(2-氧代-2-(吡咯烷-1-基)乙基)脲

2024-07-15 价格：需询单 SGC707

2021-02-06 价格：￥739.0 SGC707

2021-05-10 价格：￥需询单 N-6-异喹啉基-N-[2-氧代-2-(1-吡咯烷基)乙基]脲

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SGC707

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