NT157

更新时间： 2024-10-09 12:29:12

CAS号：1384426-12-3

常用名： (E)-3-(3-溴-4,5-二羟苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺

价格：
￥需询单/1kg ￥需询单/1g ￥需询单/1mg

纯度： 98.0%

备货期： 需询单

库存： 询单

其他详情（用途，包装）：
用途： NT157is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM) .IC50 value: 0.3 to 0.8 μM [1]Target: Insulin receptorin vitro: NT157 significantly affects the cells' migratory ability, as confirmed by a wound-healing assay. NT157 induces cytostatic effects, as evidenced by G2/M cell cycle arrest, and does not affect apoptosis. NT157, a novel small-molecule that specifically targets IRS protein, in OS cells. NT157 is a small-molecule inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1 and IRS-2. NT157 efficiently affects migration ability of MG-63 and U-2OS OS cells. NT157 treatment induces cell cycle arrest and inhibits IGF system signaling. [1] The density of LNCaP cells grown in FBS was decreased approximately 20% at 1 μM, approximately 70% at 2 μM, and >90% at 5 μM (IC50, 1.4 μM). Growth of LNCaP cells is suppressed >60% when cultured in CSS but still exhibited significant density at 2 μM and maximal decreased density at 5 μM. The density of FBS-cultured PC3 cells was similarly decreased by NT157 treatment (40% at 2 μM and > 70% at 5 μM; IC50, 2.5 μM). [2]in vivo: NT157 suppresses growth of LNCaP xenografts following castration. NT157 treatment affects IGF1R and IRS targets in xenografts and significantly delays castration-resistant progression of LNCaP androgen-responsive xenografts when combined with castration. NT157 potentiates docetaxel activity in PC3 xenografts.[2] 物理化学性质： CAS号：1384426-12-3 常用中文名：(E)-3-(3-溴-4,5-二羟苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺 常用英文名：NT157 分子式：C16H14BrNO5S 分子量：412.255 密度：1.8±0.1 g/cm3 沸点：660.3±65.0 °C at 760 mmHg 熔点：N/A 闪点：353.1±34.3 °C 储存条件：-20°C

公司名：上海楼岚生物科技有限公司

认证状态： 未认证供应商

商品数： 2474件

电话： 52996696

地址： 沪南路2729弄1310号

地区： 上海市浦东新区

联系人： 孙先生

联系人电话： 021-52996696

邮件：sales@lollanechem.com

网址：http://www.bioll.com

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公司介绍：

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥499.9/2mg ￥8999.9/100mg ￥2999.9/25mg ￥4999.9/50mg

联系人：阿拉丁

产品详情： NT157

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查看所有供应商请点击：

(E)-3-(3-溴-4,5-二羟苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺供应商

2022-03-04 价格：￥499.9 NT157

2021-02-06 价格：￥1509.0 NT157

2017-12-15 价格：￥需询单 NT-157

2021-05-10 价格：￥需询单 NT-157

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