Glycopyrrolate

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更新时间： 2025-09-01 12:36:10

CAS号：596-51-0

常用名： 甘罗溴铵

价格：
￥需询单/1g

纯度： 98.0%

备货期： 1天

库存： 现货

其他详情（用途，包装）：
用途： Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.IC50 Value:Target: mAChR (Muscarinic acetylcholine receptor M1)in vitro: Glycopyrrolate showed no selectivity in its binding to the M1-M3 receptors. Kinetics studies, however, showed that glycopyrrolate dissociates slowly from HASM muscarinic receptors (60% protection against [3H]-NMS binding at 30 nM) compared to ipratropium bromide [1].in vivo: Glycopyrrolate (1 mg) tablets were then administered, starting with one tablet daily the third week and increasing the daily dose by one tablet per week until a maximum of four tablets during week six and 4 days of week seven when the daily dose was reduced to two tablets for 3 days. glycopyrrolate can be given in controlled doses provided that an adequate medical assessment has been undertaken [2]. Glycopyrrolate has a slow and erratic absorption from the gastrointestinal system, but even low plasma levels are associated with a distinct and long-lasting antisialogic effect [3]. Oral glycopyrrolate is emerging as a potential second-line treatment option, but experience with safety, efficacy, and dosing is especially limited in children [4]. phase III study, 52.3% of glycopyrrolate oral solution recipients (aged 3-18 years; n = 137) had an mTDS response (primary endpoint); the response rate was consistently above 50% at all 4-weekly timepoints, aside from the first assessment at week 4 (40.3%). In general, glycopyrrolate oral solution was well tolerated in clinical trials. The majority of adverse events were within expectations as characteristic anticholinergic outcomes [5].Toxicity: Side effects include dry mouth, difficult urinating, heachaches, diarrhea and constipation. The medication also induces drowsiness or blurred vision. LD50=709 mg/kg (rat, oral). 物理化学性质： CAS号：596-51-0 常用中文名：甘罗溴铵常用英文名：Glycopyrrolate 分子式：C19H28BrNO3 分子量：398.335 密度：N/A 沸点：N/A 熔点：193 - 194.5ºC 闪点：N/A 储存条件：Hygroscopic, -20°C Freezer, Under Inert Atmosphere

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公司名：武汉敬康恩生物医药科技有限公司推荐

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甘罗溴铵价格

Glycopyrrolate

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