4-(3-(2H-1,2,3-Triazo-2-yl)phenylaMino)-2-((1R,2S)-2-aMinocyclohexylaMino) pyriMidine-5-carboxaMide

产品详情：

更新时间： 2025-09-16 01:12:17

CAS号：1370261-96-3

常用名： PRT062607

价格：
￥需询单/1g

纯度： 98.0%

备货期： 1天

库存： 现货

其他详情（用途，包装）：
用途： PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.IC50 value: 1-2 nM [1]Target:Syk kinase inhibitorin vitro: In human whole blood, P505-15 potently inhibited B cell antigen receptor-mediated B cell signaling and activation (IC50 0.27 and 0.28 μM, respectively) and Fcε receptor 1-mediated basophil degranulation (IC50 0.15 μM) [1]. P505-15 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL [2]. PRT318 and P505-15 effectively antagonize CLL cell survival after BCR triggering and in nurse-like cell-co-cultures. Moreover, they inhibit BCR-dependent secretion of the chemokines CCL3 and CCL4 by CLL cells, and leukemia cell migration toward the tissue homing chemokines CXCL12, CXCL13, and beneath stromal cells. PRT318 and P505-15 furthermore inhibit Syk and extracellular signal-regulated kinase phosphorylation after BCR triggering [3].in vivo: Similar levels of ex vivo inhibition were measured after dosing in mice (Syk signaling IC50 0.32 μM). Oral administration of P505-15 produced dose-dependent anti-inflammatory activity in two rodent models of rheumatoid arthritis [1]. Oral dosing in mice prevented BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model. In addition, combination treatment of primary CLL cells with P505-15 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations [2]. 物理化学性质： CAS号：1370261-96-3 常用中文名：PRT062607 常用英文名：PRT-2607 分子式：C19H23N9O 分子量：393.446 密度：1.5±0.1 g/cm3 沸点：707.6±70.0 °C at 760 mmHg 熔点：N/A 闪点：381.7±35.7 °C 储存条件：2-8℃

供应商信息：

公司名：武汉敬康恩生物医药科技有限公司推荐

认证状态： 已认证供应商

商品数： 5613件

电话： 15871494362

地址： 光谷大道58号

地区： 武汉市东西湖区

联系人： 周经理

联系人电话： 15871494362

邮件：orders@jknbiochem.com

网址：http://www.jknbiochem.com

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2024-07-15 价格：需询单 PRT062607

2021-02-06 价格：￥3746.0 BIIB-057

2022-03-04 价格：￥5100.0 PRT-2607

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PRT062607价格

4-(3-(2H-1,2,3-Triazo-2-yl)phenylaMino)-2-((1R,2S)-2-aMinocyclohexylaMino) pyriMidine-5-carboxaMide

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