AC-55541

产品详情：

发布时间： 2024-04-03 15:04:47

CAS号：916170-19-9

常用名： AC-55541

价格：
￥需询单/1mg

纯度： 98.0%

备货期： 1天

库存： 询单

其他详情（用途，包装）：
用途： AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.IC50 value: 200-1000 nM(EC50) [1]Target: PAR2 agonistNeither AC-55541 nor AC-264613 had activity at any of the other PAR receptor subtypes, nor did they have any significant affinity for over 30 other molecular targets involved in nociception. Visualization of EYFP-tagged PAR2 receptors showed that each compound stimulated internalization of PAR2 receptors. AC-55541 was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats, with elimination half-lives of 6.1 h. Intrapaw administration of AC-55541 or AC-264613 elicited robust and persistent thermal hyperalgesia and edema. Coadministration of either a tachykinin 1 (neurokinin 1) receptor antagonist or a transient receptor potential vanilloid (TRPV) 1 antagonist completely blocked these effects. Systemic administration of either AC-55541 or AC-264613 produced a similar degree of hyperalgesia as was observed when the compounds were administered locally. 物理化学性质： CAS号：916170-19-9 常用中文名：AC-55541 常用英文名：AC-55541 分子式：C25H20BrN5O3 分子量：518.362 密度：1.5±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃

供应商信息：

公司名： 武汉壹加壹生物科技有限公司推荐

认证状态： 已认证供应商

商品数： 3019件

电话： 0086-16602739303

地址： 湖北省武汉市江夏区经济开发区大桥新区邢远长工业园4#楼2楼203

地区： 武汉市江夏区

联系人： 刘经理

联系人电话： 16602739303

邮件：673003916@qq.com

主要市场：0

其他供应商价格：

2022-11-29 价格：￥需询单AC 55541

2020-12-08 价格：￥1187.0AC-55541

2022-02-19 价格：￥651.9AC 55541

2021-12-23 价格：￥988.0[Perfemiker]AC-55541,≥98%

2017-04-05 价格：￥需询单AC 55541,(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide

2021-05-10 价格：￥需询单AC-55541

2017-06-14 价格：￥需询单AC 55541

2023-09-14 价格：￥需询单AC55541

2017-11-15 价格：￥需询单(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide

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AC-55541价格

AC-55541

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