2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺

产品详情：

发布时间： 2024-04-03 15:04:47

CAS号：439239-90-4

常用名： 2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺

价格：
￥需询单/1mg

纯度： 98.0%

备货期： 1天

库存： 询单

其他详情（用途，包装）：
用途： Lasmiditan (COL-144; LY573144) is a high-affinity, highly selective 5-HT1F receptor agonist(Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively.IC50 value: 2.1 nM (Ki, 5-HT1F); >1000 nM (Ki, 5-HT1B/5-HT1D) [1]Target: 5-HT1F receptorin vitro: In vitro binding studies Lasmiditan showed a K(i) value of 2.21 nM at the 5-HT(1F) receptor, compared with K(i) values of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively, a selectivity ratio greater than 470-fold. Lasmiditan showed higher selectivity for the 5-HT(1F) receptor relative to other 5-HT(1) receptor subtypes than the first generation 5-HT(1F) receptor agonist LY334370. Unlike the 5-HT(1B/1D) receptor agonist sumatriptan, lasmiditan did not contract rabbit saphenous vein rings, a surrogate assay for human coronary artery constriction, at concentrations up to 100 μM [1].in vivo: In two rodent models of migraine, oral administration of lasmiditan potently inhibited markers associated with electrical stimulation of the trigeminal ganglion (dural plasma protein extravasation, and induction of the immediate early gene c-Fos in the trigeminal nucleus caudalis) [1]. Two RCTs in the phase II development of lasmiditan was reviewed. In the intravenous placebo-controlled RCT, lasmiditan doses of 2.5-45 mg were used, and there was a linear association between headache relief (HR) rates and dose levels (P 物理化学性质： CAS号：439239-90-4 常用中文名：2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺常用英文名：Lasmiditan 分子式：C19H18F3N3O2 分子量：377.360 密度：1.4±0.1 g/cm3 沸点：433.3±45.0 °C at 760 mmHg 熔点：N/A 闪点：215.9±28.7 °C 储存条件：2-8℃

供应商信息：

公司名： 武汉壹加壹生物科技有限公司推荐

认证状态： 已认证供应商

商品数： 4051件

电话： 0086-16602739303

地址： 湖北省武汉市江夏区经济开发区大桥新区邢远长工业园4#楼2楼203

地区： 武汉市江夏区

联系人： 刘经理

联系人电话： 16602739303

邮件：673003916@qq.com

主要市场：0

其他供应商价格：

2022-11-29 价格：￥需询单Lasmiditan (COL-144; LY573144)

2021-02-06 价格：￥2869.0Lasmiditan

2021-12-23 价格：￥1129.0[Perfemiker]Lasmiditan,98%

2023-07-19 价格：￥10054.8Lasmiditan

2021-05-10 价格：￥需询单2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺

2023-05-17 价格：￥需询单拉米地坦

2023-09-25 价格：￥需询单lasmiditan

2018-05-13 价格：￥需询单Lasmiditan

2017-11-15 价格：￥需询单2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺

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2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺价格

2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺

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