阿魏酸钠

产品详情：

发布时间： 2024-04-26 17:14:20

CAS号：24276-84-4

常用名： 阿魏酸钠

价格：
￥需询单/5mg ￥需询单/25mg ￥需询单/10g ￥需询单/50g

纯度： 98.0%

备货期： 需询单

库存： 现货

其他详情（用途，包装）：
用途： Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phenolic compound present in several plants with claimed beneficial effects in prevention and treatment of disorders linked to oxidative stress and inflammation.IC50 value:Target: 5-HT ReceptorIn vitro: In the present study we have showed that pre-treatment with Ferulic Acid (FA) reduces NO accumulation in the culture medium of LPS-induced macrophage cells. Moreover, real-time experiments have revealed that FA has an inhibitory effect at the transcriptional level on the expression of some inflammatory mediators such as IL-6, TNF-α and iNOS and an activation effect on the expression of some antioxidant molecules such as Metallothioneins (MT-1, MT-2). Importantly, we have found that FA reduced the translocation of NF-E2-related factor 2 (Nrf2) and nuclear transcription factor-κB (NF-κB) into the nuclei through a reduction of the expression of phosphorylated IKK and consequently inhibited IL-6 and NF-κB promoter activity in a luciferase assay [1]. FA treatment significantly, although not completely, protected the cells against lead acetate-induced neurite outgrowth inhibition. The effects of FA could be blocked by PD98059, zinc protoporphyrin (Zn-PP), and Nrf2 shRNA. In addition, FA induced heme oxygenase 1 (HO-1) gene expression, enhanced antioxidant response element (ARE) promoter activity, promoted ERK1/2 phosphorylation, and Nrf2 translocation in PC12 cells exposed to lead acetate. ERK1/2 locate upstream of Nrf2 and regulate Nrf2-dependent HO-1 expression in antioxidative effects of FA [2].In vivo: We aimed to verify the possible antidepressant-like effect of acute oral administration of Ferulic acid produced an antidepressant-like effect in the FST and TST (0.01–10 mg/kg, p.o.), without ccompanying changes in ambulation. The pretreatment of mice with WAY100635 (0.1 mg/kg, s.c., a selective 5-HT1A receptor ntagonist) or ketanserin (5 mg/kg, i.p., a 5-HT2A receptor ntagonist) was able to reverse the anti-immobility effect of ferulicacid (0.01 mg/kg, p.o.) in the TST. The combination of fluoxetine (5 mg/kg, p.o.), paroxetine (0.1 mg/kg, p.o.) or sertraline (1 mg/kg, p.o.) with a sub-effective dose of ferulic acid (0.001 mg/kg, p.o.) produced a synergistic antidepressant-like effect in the TST, without causing hyperlocomotion in the open-field test. ferulic acid in the forced swimming test (FST) and tail suspension test (TST) in mice [3]. 物理化学性质： CAS号：24276-84-4 常用中文名：阿魏酸钠常用英文名：Sodium Ferulate 分子式：C10H9NaO4 分子量：216.166 密度：N/A 沸点：372.3ºC at 760 mmHg 熔点：N/A 闪点：150.5ºC 储存条件：室温，密封，干燥

供应商信息：

公司名： 湖北魏氏化学试剂股份有限公司推荐

认证状态： 已认证供应商

商品数： 5506件

电话： 59102966

地址： 武汉东湖新技术开发区长城园路8号光谷精工科技园

地区： 武汉市洪山区

联系人： 张栋

联系人电话： 18717199209

邮件：2853877583@qq.com

网址：https://www.hbweishi.com/

公司介绍：
湖北魏氏化学试剂股份有限公司---公司简介
湖北魏氏化学试剂股份有限公司位于湖北武汉市东湖高新技术开发区,是一家专业从事科研分析试剂、生物缓冲剂、氨基酸衍生物、糖酸多糖类化合物、精细化学品、农用化学品、日用化学品和生物催化酶等高新技术产品研究、开发、生产和出口销售融于一体的高科技现代化民营企业,公司自创建以来坚持走“科技创新”的发展道路,高度重视科技创新研究开发工作,现货精品优质原料主要销往国内外多个国家和地区。
魏氏化学试剂采用高效运行的现代化管理模式及时有效的为国内外客户提供及时完善的产品技术服务。公司奉行以“质量为生命，科技为先导，创新求生存，诚信为本”的企业宗旨,坚持“团结拼搏,追求卓越,精益求精,合作发展”的企业理念,诚挚与国内外同仁精诚合作,互利互惠,携手共赢。

其他供应商价格：

2019-03-05 价格：￥178.0阿魏酸钠

2021-12-23 价格：￥255.0[Perfemiker]3-甲氧基-4-羟基肉桂酸钠,95%

2022-03-04 价格：￥727.9阿魏酸钠

2023-05-08 价格：￥需询单阿魏酸钠-天然提取

2016-10-29 价格：￥需询单3-甲氧基-4-羟基肉桂酸钠

2016-05-21 价格：￥需询单3-甲氧基-4-羟基肉桂酸钠

2018-02-16 价格：￥1200.0阿魏酸钠

2017-12-25 价格：￥需询单阿魏酸钠

2024-02-28 价格：￥1000.0阿魏酸钠

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