Folinic acid calcium salt hydrate

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发布时间： 2024-06-20 16:36:52

CAS号：1492-18-8

常用名： 亚叶酸钙

价格：
$需询单/1mg $需询单/100kg

纯度： 98.0%

备货期： 1天

库存： 询单

其他详情（用途，包装）：
用途： Leucovorin Calcium is a reduced folic acid.IC50 Value: 30 μM for zcSHMT and70 μM for zmSHMT [2]Target: Antifolatein vitro: Increasing concentrations of leucovorin (N5-CHO-THF) inhibit both zcSHMT and hcSHMT activities substantially, yet to a lesser extent than zmSHMT. The IC50 of leucovorin is approximately 30 μM for zcSHMT and higher than 70 μM for zmSHMT. The differential inhibition is evident with the presence of 10 μM leucovorin, the concentration estimated in serum in a high-dose leucovorin rescue regimen [2].in vivo: Following intravenous administration, peak plasma concentrations of (6R) LV, (6S) LV, and 5-CH3 THF were 148 +/- 32, 59.1 +/- 22, and 17.8 +/- 17 microM, respectively. During oral administration of LV, virtually no (6S) LV appeared in the plasma. Steady-state plasma concentrations of (6R) LV and 5-CH3 THF were approximately 1.5 +/- 0.23 and 2.8 +/- 0.41 microM, respectively [1]. 24 fasted subjects were given 4 of a series of 5 single test doses between 20 and 100 mg, at 1-week intervals, of 5-formyl-THF as an oral solution of leucovorin calcium. Six separate subjects received 200 mg iv and po in a 2-way crossover. Blood and urine samples were collected over 24 hours for differential microbiological folate assays using Lactobacillus casei and Streptococcus faecalis. Using L casei activity to measure total serum folates, the area under the concentration-time curve from 0 to infinite time (AUC[0-infinity]) was calculated. Relative bioavailabilities were 78%, 62%, 49%, and 42% for the 40-, 60-, 80-, and 100-mg doses, respectively [3].Clinical trial: Leucovorin and Fluorouracil With or Without SU-5416 in Treating Patients With Metastatic Colorectal Cancer . Phase 3 物理化学性质： CAS号：1492-18-8 常用中文名：亚叶酸钙常用英文名：Folinic acid (Calcium) 分子式：C20H21CaN7O7 分子量：511.501 密度：N/A 沸点：N/A 熔点：240-250ºC 闪点：N/A 储存条件：存放于惰性气体之中;避免光,湿气 (吸湿)

供应商信息：

公司名：Taiwan Oyi peptide Co. Ltd

认证状态： 未认证供应商

商品数： 3706件

电话： +86-13293139565

地址： China (Zhejiang) Pilot Free Trade Zone

地区： 杭州市滨江区

联系人： Vinnie

联系人电话： +86 13293139565

邮件：Jamie@api-made.com

网址：http://www.oyichem.com

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其他供应商价格：

2024-07-15 价格：需询单亚叶酸钙,水合物

2019-03-05 价格：￥278.0 亚叶酸钙,水合物

2022-11-29 价格：￥需询单 Calcium Folinate

2021-02-06 价格：￥2186.0 Folinic Acid (calcium salt)

2022-02-19 价格：￥194.9 亚叶酸钙盐水合物

2024-03-02 价格：￥6030.0 亚叶酸钙

2025-01-03 价格：￥需询单亚叶酸钙

2018-01-26 价格：￥9000.0 亚叶酸钙

2017-10-02 价格：￥需询单 Calcium folinate

2022-04-22 价格：￥需询单亚叶酸钙

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亚叶酸钙价格

Folinic acid calcium salt hydrate

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