(Rac)-Rotigotinehydrochloride

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发布时间： 2024-07-15 12:29:46

CAS号：102120-99-0

常用名： rac-Rotigotine Hydrochloride

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM. IC50 Value: 0.69 nM(Ki)Target: D-2 receptorin vitro: rac-Rotigotine showed high potency (Ki = 0.69 nM) and selectivity for D-2 receptors as compared to its potency and selectivity at various other neuronal receptors (Ki in nM): D-1 (678) dopamine, alpha 1-(534) and alpha 2-(195) adrenoceptor, S1-(6940) and S2-(5900) serotonin and muscarine (2660). Very low activity (Ki greater than 10(-5) M) was seen at the beta-adrenoceptor, A1-adenosine, GABAA and benzodiazepine receptors. Furthermore, rac-Rotigotine inhibited the calcium-dependent release of [3H]dopamine (IC50: 4 nM) and [3H]acetylcholine (IC50: 6.3 nM) from rabbit striatal slices in the nanomolar range. These effects of rac-Rotigotine were mediated through activation of D-2 dopamine autoreceptors and D-2 dopamine heteroreceptors, respectively.in vivo: Presynaptic dopaminergic activity in vivo was measurable as an inhibition of the locomotor activity of mice, and in this model rac-Rotigotine was more effective than apomorphine. Moreover, the effect of rac-Rotigotine could be antagonized by sulpiride but not by yohimbine. rac-Rotigotine was equipotent with apomorphine in inducing circling behaviour in 6-OHDA-lesioned rats. rac-Rotigotine had almost no serotonergic activity in vivo. 物理化学性质： CAS号：102120-99-0 常用中文名：rac-Rotigotine Hydrochloride 常用英文名：(Rac)-Rotigotine hydrochloride 分子式：C19H26ClNOS 分子量：351.93400 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

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2022-03-04 价格：￥2394.0 (Rac)-Rotigotine hydrochloride

2024-07-15 价格：需询单 (Rac)-Rotigotinehydrochloride

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rac-Rotigotine Hydrochloride价格

(Rac)-Rotigotinehydrochloride

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