HPGDSinhibitor1

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更新时间： 2026-05-26 15:56:25

CAS号：1033836-12-2

常用名： HPGDS抑制剂1

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.IC50 Value: 0.7 nM [1]Target: HPGDSHPGDS inhibitor 1 was elected for further profiling based on its enzyme and cell potency. The compound illustrated equal potency against purified HPGDS from human , rat, dog, and sheep (IC50, 0.5-2.3 nM). HPGDS inhibitor 1 was profiled in a panel of cellular assays to screen for activity against several relevant human enzyme targets. Those assay indicated that HPGDS inhibitor 1 does not inhibit human L- PGDS, m-PGDS, COX-1, COX-2 or 5 LOX (IC50 values > 10000 nM).HPGDS inhibitor 1 had a solubility of 1.5 ug/ml (3.9 uM) at pH 6.5. The compound had excellent PK characteristics when dosed in rats at 1 mpk with 76% bioavailavility. Rats dosed orally with 1 and 10 mpk HPGDS inhibitor 1 were sacrificed at various times, and plasma concentrations of HPGDS inhibitor 1 and spleen PGD2 concentrations were measured. Oral administration of HPGDS inhibitor 1 blocked PGD2 production in the rat spleen; inhibition of PGD2 was inversely correlated with the plasma concentration of HPGDS inhibitor 1 in a time and dose-dependent manner. Spleen PGD2 levels fall as HPGDS inhibitor 1 plasma levels increase over time; PGD2 levels return to baseline levels as HPGDS inhibitor 1 plasma levels decline. 物理化学性质： CAS号：1033836-12-2 常用中文名：HPGDS抑制剂1 常用英文名：HPGDS inhibitor 1 分子式：C19H19F4N3O 分子量：381.367 密度：1.3±0.1 g/cm3 沸点：487.2±45.0 °C at 760 mmHg 熔点：N/A 闪点：248.5±28.7 °C 储存条件：-20℃

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

联系人： 小陈

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2024-07-15 价格：需询单 HPGDSinhibitor1

2021-02-06 价格：￥10033.0 HPGDS inhibitor 1

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HPGDS抑制剂1价格

HPGDSinhibitor1

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