1-[4-[[4-[(3,4-二氯-2-氟苯基)氨基]-7-甲氧基-6-喹唑啉基]氧基]-1-哌啶基]-2-丙烯-1-酮

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发布时间： 2024-07-15 12:30:05

CAS号：1092364-38-9

常用名： 波齐奥替尼(HM781-36B)

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Poziotinib(NOV120101; HM781-36B) is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.IC50 value: 3/5/23 nM(HER1/HER2/HER4) [1]Target: pan-HER inhibitorin vitro: The IC50 levels of HM781-36B for N87 and SNU216 were 0.001 and 0.004 μmol/L, respectively, which was 10–1000 fold lower than the IC50 levels of other HER family TKIs. HM781-36B more potently inhibited the phosphorylation of HER family and downstream proteins, and induced apoptosis and G1 arrest compared to gefitinib or lapatinib [1]. HM781-36B is a potent inhibitor of EGFR in vitro, including the EGFR-acquired resistance mutation (T790M), as well as HER-2 and HER-4, compared with other EGFR tyrosine kinases inhibitors (erlotinib, lapatinib and BIBW2992). HM781-36B treatment of EGFR DelE746_A750-harboring erlotinib-sensitive HCC827 and EGFR L858R/T790M-harboring erlotinib-resistant NCI-H1975 NSCLC cells results in the inhibition of EGFR phosphorylation and the subsequent deactivation of downstream signaling proteins [2]. The addition of HM781-36B induced potent growth inhibition in both DiFi cells with EGFR overexpression and SNU-175 cells (IC50 = 0.003 and 0.005 μM, respectively). Furthermore, HM781-36B induced G1 arrest of the cell cycle and apoptosis, and reduced the levels of HER family and downstream signaling molecules, pERK and pAKT, as well as nonreceptor/cytoplasmic tyrosine kinase, BMX [3].in vivo: The growth of tumors in mice treated with HM781-36B alone or in combination with 5-FU was significantly inhibited compared with control mice, and tumor volume in mice receiving coadministraion of HM781-36B and 5-FU was smaller than tumor volume in mice receiving HM781-36B only [1]. 物理化学性质： CAS号：1092364-38-9 常用中文名：波齐奥替尼(HM781-36B) 常用英文名：Poziotinib 分子式：C23H21Cl2FN4O3 分子量：491.342 密度：1.4±0.1 g/cm3 沸点：629.7±55.0 °C at 760 mmHg 熔点：N/A 闪点：334.6±31.5 °C 储存条件：-20℃

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

联系人： 小陈

联系人电话： 0086-021-52280163

邮件：sales@echemcloud.com

网址：http://www.echemcloud.com

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2022-03-04 价格：￥888.9 波齐奥替尼（HM781-36B）

2023-11-18 价格：￥需询单 Poziotinib (HM781-36B)

2022-05-12 价格：$需询单 Poziotinib

2023-09-14 价格：￥需询单 Poziotinib

2018-09-19 价格：￥需询单波齐替尼Poziotinib

2021-05-10 价格：￥需询单波齐替尼

2020-12-08 价格：￥1140.0 波齐替尼

2019-03-19 价格：￥需询单 HM781-36B

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波齐奥替尼(HM781-36B)价格

1-[4-[[4-[(3,4-二氯-2-氟苯基)氨基]-7-甲氧基-6-喹唑啉基]氧基]-1-哌啶基]-2-丙烯-1-酮

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