Efonidipine hydrochloride

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更新时间： 2026-01-30 19:11:52

CAS号：111011-53-1

常用名： 依福地平盐酸盐

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).IC50 value: Target: calcium channel blockerin vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4].in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. The average blood pressure was comparable between the efonidipine and amlodipine periods (151 + or - 15/77 + or - 8 versus 153 + or - 15/76 + or - 8 mmHg). The pulse rate did not change significantly during the administration periods [2]. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by approximately 10%) in both groups [3]. 物理化学性质： CAS号：111011-53-1 常用中文名：依福地平盐酸盐常用英文名：Efonidipine (hydrochloride) 分子式：C34H39ClN3O7P 分子量：668.11600 密度：N/A 沸点：746.9ºC at 760 mmHg 熔点：169-170ºC 闪点：405.5ºC 储存条件：2-8℃

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2022-03-04 价格：￥2708.0 盐酸依非地平

2024-07-15 价格：需询单 Efonidipine hydrochloride

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依福地平盐酸盐价格

Efonidipine hydrochloride

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