VU0357017盐酸盐

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发布时间： 2024-07-15 12:30:13

CAS号：1135242-13-5

常用名： VU0357017盐酸盐

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纯度： 99.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15).IC50 value: 477 ± 172 nM (EC50) [1]Target: M1in vitro: VU0357017 is a M1-selective agonists that appear to activate M1 through actions at an allosteric site. Ki values of VU0357017 derived from competition binding experiment is 9.91(rM1), 21.4 (rM2), 55.3 (rM3), 35 (rM4), and 50 (rM5), respectively. [1] VU0357017 is a potent and efficacious M1 agonist, selective versus M2 M5 family members and allosteric agonist. VU0357017 is a highly selective M1 agonist suggests that these compounds are unlikely to act at the highly conserved orthosteric site on M1 and are more likely to act as allosteric agonists. [2] VU0357017 has robust effects on M1-activation of calcium mobilization and ERK1/2 phosphorylation but have little effect on β-arrestin recruitment. VU0357017 induces calcium release and ERK phosphorylation but is without effects on β-arrestin recruitment. VU0357017 significantly enhances threshold Θ-burst LTP and VU0364572 induces LTD at the Schaffer collateral-CA1 synapse of rodent hippocampal slices. [3]in vivo: VU0357017 has robust efficacy in improving hippocampal-dependent learning in rats. VU0357017 enhances performance in Morris water maze and contextual fear conditioning in rats. [3] 物理化学性质： CAS号：1135242-13-5 常用中文名：VU0357017盐酸盐常用英文名：VU0357017 分子式：C18H28ClN3O3 分子量：369.88600 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

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公司名：上海念兴实业有限公司推荐

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2024-03-12 价格：￥3999.9 VU 0357017 Hydrochloride

2024-07-15 价格：需询单 VU0357017盐酸盐

2023-02-25 价格：￥需询单 VU0357017

2023-09-22 价格：￥需询单 VU0357017

2021-02-06 价格：￥5389.0 VU 0357017 hydrochloride

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VU0357017盐酸盐价格

VU0357017盐酸盐

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