利赛膦酸钠

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发布时间： 2024-07-15 12:30:18

CAS号：115436-72-1

常用名： 利赛膦酸钠

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Risedronate sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.Target: Risedronate sodium, which was promoted in Croatia a few months ago, is the latest (III) generation of bisphosphonates, the most efficient anti-resorption drugs that inhibit osteoclast-mediated bone resorption and change the bone metabolism. Risedronate sodium is hence the first line of bisphosphonates for the reduction of vertebral and non-vertebral fracture risks in postmenopausal women with osteoporosis or those with a high risk of osteoporosis. It also efficiently prevents bone loss or improves bone density in men and women on a long-term corticosteroid therapy [1].The administration of 20 and 25 mg/kg risedronate sodium for 4 days led to decreases of parasitemia of 68.9% and 83.6%, respectively. On the seventh day of treatment the inhibitions were 63% and 88.9% with 20 and 25 mg/kg, respectively. After recovering the parasitemia, a dose-response curve was obtained for estimating the ID50 (dose causing 50% inhibition), equivalent to 17 ± 1.8 mg/kg after 7 days of treatment. Four days after the interruption of treatment (11 days postinfection), the parasitemias of the groups treated with 10, 15, 20, and 25 mg/kg/day were 15.3%, 15.9%, 15.2%, and 5.7%, respectively. Conversely, the group that received PBS presented parasitemia of 25.6%. Among the groups treated with risedronate sodium, only the animals that received 25 mg/kg had a significant inhibition of 77.8% (see Table S1 in the supplemental material), demonstrating that even after treatment discontinuation, the parasitemia of the animals remained low in relation to that of the controls [2].Clinical indications: Bone resorption; Male osteoporosis; Osteogenesis imperfecta; Osteoporosis; Pagets bone disease Toxicity: abdominal pain; anxiety, back pain; belching, bladder irritation; bone disorders and pain; bronchitis; bursitis; cataracts; chest pain; colitis; constipation; depression; diarrhea; difficulty breathing 物理化学性质： CAS号：115436-72-1 常用中文名：利赛膦酸钠常用英文名：Sodium risedronate 分子式：C7H10NNaO7P2 分子量：305.094 密度：N/A 沸点：692.3ºC at 760 mmHg 熔点：252-262°C 闪点：372.5ºC 储存条件：Store at RT

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公司名：上海念兴实业有限公司推荐

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2022-02-19 价格：￥137.9 利塞膦酸钠

2024-07-15 价格：需询单利赛膦酸钠

2019-03-05 价格：￥2698.0 利赛膦酸钠

2022-11-03 价格：￥2400.0 利赛膦酸钠

2024-05-08 价格：￥4550.0 利塞膦酸钠

2021-02-06 价格：￥789.0 Risedronate Sodium

2024-01-09 价格：$需询单 Risedronate sodium

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