ITI214(freebase)

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发布时间： 2024-07-15 12:30:21

CAS号：1160521-50-5

常用名： ITI214自由基

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： ITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).IC50 value: 58 pM (Ki)Target: PDE1in vitro: ITI-214 exhibits picomolar inhibitory potency for PDE1, demonstrates excellent selectivity against all other PDE families. ITI214 exhibits excellent selectivity over other PDE familymembers. For instance, the Ki values of ITI214 against recombinant full-length human PDE1A, PDE1B, and PDE1C are 33 pM, 380 pM, and 35 pM, respectively. ITI214 is profiled in a panel of enzymes, receptors, transporters, and ion channels from Caliper at 10 μM, which is over 170000 times higher than its Ki for PDE1, and demonstrates good selectivity. [1]in vivo: ITI214 possesses a good overall profile with balanced physicochemical properties, excellent potency and selectivity, and good pharmacokinetics. ITI214 is found to significantly enhance memory performance in the test with a minimum effective dose of 3 mg/kg. [1] 物理化学性质： CAS号：1160521-50-5 常用中文名：ITI214自由基常用英文名：ITI214 free base 分子式：C29H26FN7O 分子量：507.561 密度：1.5±0.1 g/cm3 沸点：731.7±70.0 °C at 760 mmHg 熔点：N/A 闪点：396.3±35.7 °C 储存条件：-20°C，密闭，干燥

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ITI214(freebase)

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