(S)-N-甲基-3-(萘-1-基氧)-3-(噻吩-2-基)丙烷-1-胺

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发布时间： 2024-07-15 12:30:22

CAS号：116539-59-4

常用名： 度洛西汀

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纯度： 99.0%

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用途： Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Target: SNRIsDuloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system. Duloxetine is also considered a less potent inhibitor of dopamine reuptake. However, duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors and can therefore be considered to be a selective reuptake inhibitor at the 5-HT and NA transporters. Duloxetine undergoes extensive metabolism, but the major circulating metabolites do not contribute significantly to the pharmacologic activity. Major depressive disorder is believed to be due in part to an increase in pro-inflammatory cytokines within the central nervous system. Antidepressants including ones with a similar mechanism of action as duloxetine, i.e. serotonin metabolism inhibition, cause a decrease in proinflammatory cytokine activity and an increase in anti-inflammatory cytokines; this mechanism may apply to duloxetine in its effect on depression but research on cytokines specific to duloxetine therapy is lacking [1]. The analgesic properties of duloxetine in the treatment of diabetic neuropathy and central pain syndromes such as fibromyalgia are believed to be due to sodium ion channel blockade [2]. 物理化学性质： CAS号：116539-59-4 常用中文名：度洛西汀常用英文名：Duloxetine 分子式：C18H19NOS 分子量：297.41 密度：1.2±0.1 g/cm3 沸点：466.2±40.0 °C at 760 mmHg 熔点：N/A 闪点：235.7±27.3 °C 储存条件：-20℃

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2022-03-04 价格：￥720.9 度洛西汀

2024-07-15 价格：需询单 (S)-N-甲基-3-(萘-1-基氧)-3-(噻吩-2-基)丙烷-1-胺

2017-09-09 价格：￥需询单 Duloxetinev

2024-05-21 价格：￥需询单度洛西汀

2024-01-09 价格：$需询单 116539-59-4

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度洛西汀价格

(S)-N-甲基-3-(萘-1-基氧)-3-(噻吩-2-基)丙烷-1-胺

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