ZiprasidoneHCl

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更新时间： 2025-12-30 13:42:48

CAS号：122883-93-6

常用名： 盐酸齐拉西酮

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.Target: 5-HT receptor; Dopamine receptorZiprasidone (hydrochloride) is the salt form of ziprasidone, which possesses an in vitro 5-HT2A/dopamine D2 receptor affinity ratio higher than any clinically available antipsychotic agent. In vivo, ziprasidone antagonizes 5-HT2A receptor-induced head twitch with 6-fold higher potency than for blockade of d-amphetamine-induced hyperactivity, a measure of central dopamine D2 receptor antagonism. Ziprasidone also has high affinity for the 5-HT1A, 5-HT1D and 5-HT2C receptor subtypes, which may further enhance its therapeutic potential [1]. Ziprasidone sulfoxide and sulfone were the major metabolites in human serum. The affinities of the sulfoxide and sulfone metabolites for 5-HT2 and D2 receptors are low with respect to ziprasidone, and are thus unlikely to contribute to its antipsychotic effects [2]. Ziprasidone was associated with significant differential adverse effects relative to placebo in BPM, BPD, and schizophrenia with no significant difference in weight gain in all 3 groups. Self-reported somnolence was increased across the 3 conditions. Subjects with BPM were more vulnerable to EPS than those with BPD or schizophrenia [3].Clinical indications: Bipolar I disorder; Bipolar disorder; Mania; SchizophreniaFDA Approved Date: February 2001 物理化学性质： CAS号：122883-93-6 常用中文名：盐酸齐拉西酮常用英文名：Ziprasidone HCl 分子式：C21H22Cl2N4OS 分子量：449.397 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：室温，干燥

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2024-07-15 价格：需询单 ZiprasidoneHCl

2022-02-19 价格：￥72.9 Ziprasidone HCl

2021-02-06 价格：￥989.0 Ziprasidone HCl

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盐酸齐拉西酮价格

ZiprasidoneHCl

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