Tolterodine

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发布时间： 2024-07-15 12:30:59

CAS号：124937-51-5

常用名： 托特罗定

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value:Target: mAChRin vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors [1].in vivo: Tolterodine was extensively metabolized in vivo [2]. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased [3]. 物理化学性质： CAS号：124937-51-5 常用中文名：托特罗定常用英文名：Tolterodine-L-tartrate 分子式：C22H31NO 分子量：325.488 密度：1.0±0.1 g/cm3 沸点：442.2±45.0 °C at 760 mmHg 熔点：N/A 闪点：192.1±27.4 °C 储存条件：-20°C Freezer

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2022-03-04 价格：￥770.0 Tolterodine-L-tartrate

2024-07-15 价格：需询单 Tolterodine

2021-02-06 价格：￥4689.0 (R)-(+)-Tolterodine

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托特罗定价格

Tolterodine

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