Noscapine

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发布时间： 2024-07-15 12:31:15

CAS号：128-62-1

常用名： 那可丁

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纯度： 99.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Noscapine is an orally administrable drug used worldwide for cough suppression, primarily mediated by its σ-receptor agonist activity, and possess anticancer activity.Target: σ-receptorin vitro: Noscapine is a phthalideisoquinoline alkaloid from opium, is a recently discovered anticancer drug and is currently under investigation in phase-I/II clinical trials for the treatment of leukemia and lymphoma. Noscapine causes few or no side effects and has been widely used as a cough suppressant in developing countries. Noscapine has been demonstrated to interact with microtubules. Interestingly, unlike many other microtubule-targeting agents such as Paclitaxel and Nocodazole, Noscapine does not obviously affect the total amount of microtubule polymers in cells; instead, it significantly increases the time microtubules spend in the pause state. The alteration of microtubule dynamics then activates the spindle checkpoint and arrests cell cycle progression at mitosis, leading to apoptotic cell death. 物理化学性质： CAS号：128-62-1 常用中文名：那可丁常用英文名：Noscapine 分子式：C22H23NO7 分子量：413.421 密度：1.3±0.1 g/cm3 沸点：565.3±50.0 °C at 760 mmHg 熔点：174-176ºC 闪点：295.7±30.1 °C 储存条件：-20℃

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

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2022-03-04 价格：￥259.0 Noscapine

2024-07-15 价格：需询单 Noscapine

2022-05-12 价格：$需询单 Narcotine

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Noscapine

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