SKLB4771
产品详情：
发布时间： 2024-07-15 12:31:45
CAS号：1370256-78-2
常用名：
价格：
纯度： 98.0%
备货期： 10天
库存： 现货
其他详情（用途，包装）：
用途： SKLB4771 is a novel potent and selective Flt3 inhibitor with IC50 of 10 nM; against FLT3-ITD-expressing MV4-11 cells with IC50 of 6 nM.IC50 value: 10 nM (in vitro) [1]Target: in vitro: SKLB4771 inhibited FLT3 phosphorylation in a dose-dependent manner. Consistent with the downregulation of the phosphorylation of FLT3, the phosphorylation of the downstream signaling proteins STAT5 and ERK1/2 was also significantly inhibited at concentrations >0.1 μM. SKLB4771 potently inhibited the growth of MV4-11 cells that express FLT3-ITD, with an IC50 value of 0.006 μM. It just exhibited very weak inhibitory activity against human T lymphoma Jurkat cells, human Burkitt's lymphoma Ramos cells, human lung cancer PC-9 and H292 cells, and human epithelial carcinoma A431 cells (IC50: 3.05 μM, 6.25 μM, 3.72 μM, 6.94 μM, and 8.91 μM, respectively). For other leukemia and solid tumor cell lines, including K562, U937, Karpas299, HCC827, A549, H2228, H820, MDA-MB-231, BT474, MCF-7, HCT116, SW480, LoVo, HeLa, SKOV-3, SK, DU145, PC-3, A431, and SH-SY5Y [1].in vivo: Treatment with SKLB4771 at 100 mg/kg/d resulted in rapid and complete tumor regression in all mice of this group. SKLB4771 treatment at 20 mg/kg/d and 40 mg/kg/d significantly slowed down the tumor growth; the tumor inhibition rates are 66% and 84%, respectively. Moreover, during the whole experiment, no significant weight loss or any other obvious signs of toxicity were observed for all of the SKLB4771 treated mice. 物理化学性质： CAS号：1370256-78-2 常用中文名：SKLB4771 常用英文名：FLT3-IN-1 分子式：C25H27N7O3S2 分子量：537.65700 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃
供应商信息：
公司名：上海念兴实业有限公司 推荐
认证状态： 已认证供应商
商品数： 403768件
电话： 18916513247
地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区： 上海市普陀区
联系人： 小陈
联系人电话： 0086-021-52280163
邮件：sales@echemcloud.com
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2022-09-23 价格：￥2592.0
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SKLB4771价格为, 由SKLB4771生产厂家上海念兴实业有限公司提供，供应信息包括纯度，备货期/库存，供货能力等。>>电脑版：SKLB4771_价格_生产厂家【上海念兴实业有限公司】
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