2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E

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更新时间： 2026-01-26 20:25:05

CAS号：141286-78-4

常用名： PEPA

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.IC50 value:Target: AMPAR modulatorin vitro: PEPA dose-dependently potentiated AMPA-induced increase of [Ca2+]i. In 90% (72 out of 80) of the cells in which cyclothiazide acts, PEPA potentiated the increased [Ca2+]i induced by AMPA with pronounced cell-to-cell variation in rat hippocampal cultures [1]. PEPA bound to the binding domains of the GluA2 and GluA3 flop isoforms of AMPA receptors [2]. coapplication of AMPA with PEPA protected hippocampal CA1 neurons from brain ischemia-induced death. Coapplication of AMPA with PEPA could prevent downregulated expression of GluR2 subunit caused by ischemia and increase BDNF expression via Lyn-ERK1/2-CREB signaling [4].in vivo: PEPA (3, 10, 30mg/kg body weight) or vehicle was intraperitoneally administered into stressed mice once before the first extinction session. The significant decrease of the freezing response in the extinction sessions was only seen in the 30mg/kg PEPA-administered stressed mice, compared with vehicle-administered stressed mice [3]. 物理化学性质： CAS号：141286-78-4 常用中文名：PEPA 常用英文名：PEPA 分子式：C16H16F2N2O4S2 分子量：402.43600 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

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2022-03-04 价格：￥3791.0 PEPA

2024-07-15 价格：需询单 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E

2021-02-06 价格：￥1609.0 PEPA

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PEPA价格

2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E

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