2,3-双(4-羟苯基)丙腈

产品详情：

发布时间： 2024-07-15 12:32:03

CAS号：1428-67-7

常用名： 2,3-双(4-羟苯基)丙腈

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Diarylpropionitrile(DPN) is a non-steroidal estrogen receptor β(ER β) selective ligand.IC50 value:Target: ER β ligandin vitro: Pre-treatment with 1-100 nM DPN significantly decreased neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2, thereby mitigating apoptotic morphological alterations. DPN pre-treatment decreased the expression levels of pro-inflammatory cytokines IL-1β and IL-6 through attenuation of Aβ1-42-induced phosphorylation of mitogen-activated protein kinases JNK and p38. In addition, DPN enhanced ERK1/2 and Akt phosphorylation depressed by Aβ1-42 [1]. ERβ was expressed in RAW264.7 cells, and DPN statistically significantly decreased LPS-induced RANTES production in RAW264.7 cells. Small interfering RNA targeting the ERβ gene inhibited the effect of DPN on RANTES production. In addition, DPN inhibited nuclear translocation and phosphorylation of p65 by inhibiting IκB degradation and thus prohibited the activation of nuclear factor κB (NF-κB) [3].in vivo: DPN treatment during EAE did not attenuate demyelination, only partially improved axon conduction, and did not activate the phosphatidylinositol 3-kinase/serine-threonine-specific protein kinase/mammalian target of rapamycin signaling pathway in ERβ CKO mice [2]. 物理化学性质： CAS号：1428-67-7 常用中文名：2,3-双(4-羟苯基)丙腈常用英文名：2,3-bis(4-hydroxyphenyl)propionitrile 分子式：C15H13NO2 分子量：239.269 密度：1.3±0.1 g/cm3 沸点：449.4±35.0 °C at 760 mmHg 熔点：203°C 闪点：225.6±25.9 °C 储存条件：-20°C

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

联系人： 小陈

联系人电话： 0086-021-52280163

邮件：sales@echemcloud.com

网址：http://www.echemcloud.com

主要市场：

年贸易额：

外贸占销售比例：

主要合作伙伴：

公司介绍：

其他供应商价格：

2022-02-19 价格：￥478.9 2,3-双(4-羟苯基)丙腈

2024-07-15 价格：需询单 2,3-双(4-羟苯基)丙腈

2021-02-06 价格：￥1177.0 DPN

查看所有价格请点击：

2,3-双(4-羟苯基)丙腈价格

2,3-双(4-羟苯基)丙腈

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：