CTX0294885

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发布时间： 2024-07-15 12:32:06

CAS号：1439934-41-4

常用名： CTX-0294885

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： CTX-0294885 is a a novel bisanilino pyrimidine; exhibits inhibitory activity against a broad range of kinases in vitro, and further developed it into a Sepharose-supported kinase capture reagent.Target: Kinase capture reagentUse of a quantitative proteomics approach confirmed the selectivity of CTx-0294885-bound beads for kinase enrichment. Large-scale CTx-0294885-based affinity purification followed by LC-MS/MS led to the identification of 235 protein kinases from MDA-MB-231 cells, including all members of the AKT family that had not been previously detected by other broad-spectrum kinase inhibitors. Addition of CTx-0294885 to a mixture of three kinase inhibitors commonly used for kinase-enrichment increased the number of kinase identifications to 261, representing the largest kinome coverage from a single cell line reported to date. Coupling phosphopeptide enrichment with affinity purification using the four inhibitors enabled the identification of 799 high-confidence phosphosites on 183 kinases, ～10% of which were localized to the activation loop, and included previously unreported phosphosites on BMP2K, MELK, HIPK2, and PRKDC. Therefore, CTx-0294885 represents a powerful new reagent for analysis of kinome signaling networks that may facilitate development of targeted therapeutic strategies. 物理化学性质： CAS号：1439934-41-4 常用中文名：CTX-0294885 常用英文名：CTX0294885 分子式：C22H24ClN7O 分子量：437.925 密度：1.3±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃

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公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

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地区： 上海市普陀区

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2024-07-15 价格：需询单 CTX0294885

2022-11-29 价格：￥需询单 CTX0294885

2021-02-06 价格：￥1569.0 CTX0294885

2022-03-04 价格：￥6385.9 CTX0294885

2023-09-12 价格：￥需询单 CTX0294885

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CTX-0294885价格

CTX0294885

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