阿齐沙坦

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发布时间： 2024-07-15 12:32:16

CAS号：147403-03-0

常用名： 阿齐沙坦

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Azilsartan(TAK-536) is a specific and potent angiotensin II type 1 receptor antagonist with IC50 of 2.6 nM.IC50 Value: 2.6 nM [1]Target: AT1 receptorin vitro: Azilsartan inhibited the specific binding of 125I-Sar1-Ile8-AII to human angiotensin type 1 receptors with an IC50 of 2.6 nM. The inhibitory effect of AZL persisted after washout of the free compound (IC(50) value of 7.4 nM). AZL also inhibited the accumulation of AII-induced inositol 1-phosphate (IP1) in the cell-based assay with an IC50 value of 9.2 nmol; this effect was resistant to washout (IC50 value of 81.3 nM). Olmesartan and valsartan inhibited IP1 accumulation with IC50 values of 12.2 and 59.8 nM, respectively [1]. Azilsartan is not readily biodegradable. Results of the water sediment study demonstrated significant shifting of azilsartan metabolites to sediment. Based on the equilibrium partitioning method, metabolites are unlikely to pose a risk to sediment-dwelling organisms [2].in vivo: In 4 randomized controlled trials (3 published to date), azilsartan medoxomil/chlorthalidone 40 mg/12.5 mg and 40 mg/25 mg reduced blood pressure (BP) significantly more than comparators did, including an approximately 5-mm Hg greater BP reduction than olmesartan medoxomil/hydrochlorothiazide 40 mg/25 mg and azilsartanmedoxomil/hydrochlorothiazide [3]. Both TAK-536 and candesartan suppressed the increase in plasma glucose level in the OGTT without significant change in insulin concentration and improved insulin sensitivity. In adipose tissue, TAK-536 and candesartan reduced TNF-alpha expression but increased the expression of adiponectin, PPARgamma, C/EBalpha, and aP2 [4].Clinical trial: New Angiotensin II Receptor Blocker Azilsartan Study for Stronger Blood Pressure Lowering . Phase4 物理化学性质： CAS号：147403-03-0 常用中文名：阿齐沙坦常用英文名：Azilsartan 分子式：C25H20N4O5 分子量：456.450 密度：1.4±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8°C

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公司名：上海念兴实业有限公司推荐

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2024-07-15 价格：需询单阿齐沙坦

2022-09-16 价格：￥650.0 阿齐沙坦

2018-04-16 价格：￥需询单 Azilsartan

2020-01-15 价格：￥6500.0 阿齐沙坦

2017-12-08 价格：￥需询单阿齐沙坦

2020-12-08 价格：￥需询单阿齐沙坦

2022-05-12 价格：$需询单 Azilsartan

2017-09-30 价格：￥需询单阿齐沙坦

2023-09-06 价格：￥需询单 Azilsartan

2017-06-13 价格：￥需询单阿齐沙坦

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