Azimilide

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更新时间： 2025-12-31 21:03:39

CAS号：149908-53-2

常用名： 阿齐利特

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.IC50 value:Target: in vitro: Azimilide blocked HERG channels at 0.1 and 1 Hz with IC50s of 1.4 microM and 5.2 microM respectively. Azimilide blockade of HERG channels expressed in Xenopus oocytes and I(Kr) in mouse AT-1 cells was decreased under conditions of high [K+]e, whereas block of slowly activating I(Ks) channels was not affected by changes in [K+]e [1]. Azimilide suppressed the following currents (Kd in parenthesis): IKr ( or = 50 microM at +50 and -140 mV, respectively). Azimilide blocked IKr, IKs, and INa in a use-dependent manner. Furthermore, azimilide reduced a slowly inactivating component of Na current that might be important for maintaining the action potential plateau in canine ventricular myocytes [2]. In guinea pig ventricular myocytes, NE-10064 (0.3-3 microM) significantly prolonged action potential duration (APD) at 1 Hz. At 3 Hz, NE-10064 (0.3-1 microM) increased APD only slightly, and at 10 microM decreased APD and the plateau potential. NE-10064 potently blocked the rapidly activating component of the delayed rectifier, IKr (IC50 0.4 microM), and inhibited IKs (IC50 3 microM) with nearly 10-fold less potency [3].in vivo: NE-10064 (10 mg/kg intravenously, i.v.) reduced (p 物理化学性质： CAS号：149908-53-2 常用中文名：阿齐利特常用英文名：Azimilide 分子式：C23H28ClN5O3 分子量：457.95300 密度：1.32 g/cm3 沸点：594.9ºC at 760 mmHg 熔点：N/A 闪点：313.6ºC 储存条件：2-8℃

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公司名：上海念兴实业有限公司推荐

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2024-07-15 价格：需询单 Azimilide

2021-02-06 价格：￥559.0 Azimilide

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阿齐利特价格

Azimilide

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