盐酸西维美林半水合物

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发布时间： 2024-07-15 12:32:26

CAS号：153504-70-2

常用名： 盐酸西维美林

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纯度： 98.0%

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用途： Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. IC50 value:Target: mAChRThe general pharmacol. properties of this drug on the gastrointestinal, urinary, and reproductive systems and other tissues were investigated in mice, rats, guinea pigs, rabbits, and dogs. The in vitro metab. of SNI-2011 was also evaluated with rat and dog liver microsomes. After oral administration, plasma concns. of SNI-2011 reached to Cmax within 1 h in both species, suggesting that SNI-2011 was quickly absorbed, and then decreased with a t1/2 of 0.4-1.1 h. The bioavailability was 50% and 30% in rats and dogs, resp. Major metabolites in plasma were both S- and N-oxidized metabolites in rats and only N-oxidized metabolite in dogs, indicating that a large species difference was obsd. in the metab. of SNI-2011. Sex difference was also obsd. in the pharmacokinetics of SNI-2011 in rats, but not in dogs. In the in vitro study, chem. inhibition and pH-dependent studies revealed that the sulfoxidn. and N-oxidn. of SNI-2011 were mediated by cytochrome P 450 (CYP) and flavin-contg. monooxygenase (FMO), resp., in both species. In addn., CYP2D and CYP3A were mainly responsible for the sulfoxidn. in rat liver microsomes. 物理化学性质： CAS号：153504-70-2 常用中文名：盐酸西维美林常用英文名：Cevimeline hydrochloride hemihydrate 分子式：C20H35ClN2O2S2 分子量：435.09 密度：1.19g/cm3 沸点：308.5ºC at 760mmHg 熔点：N/A 闪点：140.4ºC 储存条件：-20°C

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2022-02-19 价格：￥1503.9 盐酸西维美林半水合物

2021-02-06 价格：￥28529.0 Cevimeline hydrochloride hemihydrate

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盐酸西维美林半水合物

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