盐酸曲吡那敏

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发布时间： 2024-07-15 12:32:27

CAS号：154-69-8

常用名： 盐酸曲吡那敏

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纯度： 98.0%

备货期： 10天

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用途： Tripelennamine Hcl, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.IC50 Value:Target: Histamine H1 receptorTripelennamine can be used in the treatment of asthma, hay fever, rhinitus and urticaria.in vitro: Arterial and mixed venous blood-gas and pH measurements were made at rest before and after saline or drug administration and during incremental exercise leading to maximal exertion at 14 m/s on 3.5% uphill grade for 120 s. Galloping at this workload elicited maximal heart rate and induced exercise-induced pulmonary hemorrhage in all horses in both treatments, thereby indicating that capillary stress failure-related pulmonary injury had occurred [1].in vivo: The data obtained (median and range in brackets) in camels and horses, respectively, were as follows: the terminal elimination half-lives were 2.39 (1.91-6.54) and 2.08 (1.31-5.65) h, total body clearances were 0.97 (0.82-1.42) and 0.84 (0.64-1.17)L/h/kg. The volumes of distribution at steady state were 2.87 (1.59-6.67) and 1.69 (1.18-3.50) L/kg, the volumes of the central compartment of the two compartment pharmacokinetic model were 1.75 (0.68-2.27) and 1.06 (0.91-2.20) L/kg [2]. After intramuscular administration of 50 or 100 mg tripelennamine, mean plasma concentrations at 30 minutes were 105 and 194 ng/ml, respectively, and mean plasma t1/2 values were 2.9 and 4.4 hours, respectively [3]. 物理化学性质： CAS号：154-69-8 常用中文名：盐酸曲吡那敏常用英文名：Tripelennamine (hydrochloride) 分子式：C16H22ClN3 分子量：291.81900 密度：1.20 沸点：387.8ºC at 760 mmHg 熔点：192-193ºC 闪点：188.3ºC 储存条件：Refrigerator

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2022-03-04 价格：￥61.9 盐酸曲吡那敏

2024-07-15 价格：需询单盐酸曲吡那敏

2021-02-06 价格：￥659.0 Tripelennamine HCl

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