(E)-3-(2,4-二甲氧基苯基)亚甲基)-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐

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发布时间： 2024-07-15 12:32:30

CAS号：156223-05-1

常用名： GTS-21二盐酸盐(DMBX-A)

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纯度： 99.0%

备货期： 10天

库存： 现货

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用途： GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Target: nAChRin vitro: GTS-21 is one of the most potent α7nAChR agonists, has been reported to attenuate pro-inflammatory cytokine production, improve outcomes in sepsis models, pancreatitis, and ischemia-reperfusion injury, and inhibit the production of endotoxin-induced TNF in lung tissue. In addition, recent studies have demonstrated that GTS-21 inhibits the activities of endothelial cells and monocyte macrophages, as well as the secretion of pro-inflammatory cytokines in peripheral blood samples, by regulating the JAK2-STAT3 pathway. [1] in vivo: In septic animals, GTS-21 significantly ameliorated GI motility, lowered systemic and colonic levels of IL-6, decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing sepsis-induced ileus. Chrna7 mice displayed a more severe septic phenotype, whereas GTS-21 remarkably was also beneficial in these animals. [2] 物理化学性质： CAS号：156223-05-1 常用中文名：GTS-21二盐酸盐(DMBX-A) 常用英文名：GTS-21 分子式：C19H22Cl2N2O2 分子量：381.30 密度：1.1±0.1 g/cm3 沸点：485.6±45.0 °C at 760 mmHg 熔点：216-217℃ (decomposition) 闪点：247.5±28.7 °C 储存条件：2-8°C

供应商信息：

公司名：上海念兴实业有限公司推荐

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地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

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2022-02-19 价格：￥407.9 GTS-21二盐酸盐（DMBX-A）

2024-07-15 价格：需询单 (E)-3-(2,4-二甲氧基苯基)亚甲基)-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐

2022-02-11 价格：￥需询单 GTS-21

2021-02-06 价格：￥3829.0 GTS 21 dihydrochloride

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GTS-21二盐酸盐(DMBX-A)价格

(E)-3-(2,4-二甲氧基苯基)亚甲基)-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐

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