N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

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发布时间： 2024-07-15 12:32:31

CAS号：157115-85-0

常用名： N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.IC50 Value:Target: in vitro: Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) [1]. GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action [2].in vivo: N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit [3]. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions [4]. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively) [5].Toxicity: Noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity [6]. Clinical trial: Discontinued 物理化学性质： CAS号：157115-85-0 常用中文名：N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯常用英文名：Noopept 分子式：C17H22N2O4 分子量：318.368 密度：1.2±0.1 g/cm3 沸点：547.3±50.0 °C at 760 mmHg 熔点：94.0 to 98.0 °C 闪点：284.8±30.1 °C 储存条件：-20°C

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公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403769件

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2024-07-15 价格：需询单 N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

2022-03-30 价格：￥需询单 N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

2019-03-05 价格：￥2688.0 N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

2022-02-19 价格：￥1102.9 Noopept

2022-11-03 价格：￥需询单 N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

2025-01-15 价格：￥需询单 N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

2024-04-26 价格：￥需询单 N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

2020-03-20 价格：￥2200.0 N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

2017-12-07 价格：$需询单 Nopept

2023-09-15 价格：￥需询单 Noopept

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N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯价格

N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

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