(-)-1-(3-羟丙基)-5-[(2R)-2-[[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2,3-二氢-1H-吲哚-7-甲酰胺

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更新时间： 2026-02-03 17:38:58

CAS号：160970-54-7

常用名： 西洛多辛

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纯度： 99.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Silodosin (Rapaflo; KMD-3213) is an α1-adrenoceptor antagonist with high uroselectivity; In treatment of dysuria.IC50 Value:Target: Adrenergic Receptorin vitro: Silodosin potently inhibited 2-[2-(4-hydroxy-3-[125I]iodophenyl)ethylaminomethyl]-alpha-tetralone binding to the cloned human alpha 1a-AR, with a Ki value of 0.036 nM, but had 583- and 56-fold lower potency at the alpha 1b- and alpha 1d-ARs, respectively. Silodosin inhibited norepinephrine-induced increases in intracellular Ca2+ concentrations in alpha 1a-AR-expressing Chinese hamster ovary cells with an IC50 of 0.32 nM but had a much weaker inhibitory effect on the alpha 1b- and alpha 1d-ARs.in vivo: Using pharmacologically well characterized native rat tissues [submaxillary gland (alpha 1A-AR-expressing tissue), liver (alpha 1B-AR-expressing tissue), and heart (mixed alpha 1A- and alpha 1B-AR-expressing tissue)], binding studies showed that inhibition curves for Silodosin in submaxillary gland and liver best fit a one-site model (with Ki values of 0.15 and 16 nM, respectively), whereas Silodosin had high and low affinity sites in heart membranes. Chloroethylclonidine treatment of rat heart membranes completely eliminated the low affinity sites for Silodosin. Furthermore, in human liver and prostate Silodosin could identify high and low affinity sites, the Ki values of which corresponded well to those for the cloned human alpha 1a- and alpha 1b-ARs, respectively. Moreover, the affinity of Silodosin was found to be approximately 10-fold higher at the cloned human alpha 1a-AR than at the cloned rat alpha 1a-AR.v 物理化学性质： CAS号：160970-54-7 常用中文名：西洛多辛常用英文名：Silodosin 分子式：C25H32F3N3O4 分子量：495.534 密度：1.2±0.1 g/cm3 沸点：601.4±55.0 °C at 760 mmHg 熔点：107 °C 闪点：317.5±31.5 °C 储存条件：存放于惰性气体之中;避免空气

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2022-02-19 价格：￥108.9 Silodosin

2024-07-15 价格：需询单 (-)-1-(3-羟丙基)-5-[(2R)-2-[[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2,3-二氢-1H-吲哚-7-甲酰胺

2019-03-05 价格：￥1968.0 西洛多辛

2023-06-26 价格：￥93.0 西洛多辛

2017-07-11 价格：￥需询单西洛多辛

2017-07-07 价格：￥需询单西洛多辛

2018-05-13 价格：￥需询单西洛多辛

2017-12-17 价格：￥12000.0 西洛多辛

2021-04-15 价格：￥20000.0 西洛多辛，赛洛多辛，Silodosin

2023-09-06 价格：￥需询单西洛多辛（R）

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西洛多辛价格

(-)-1-(3-羟丙基)-5-[(2R)-2-[[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2,3-二氢-1H-吲哚-7-甲酰胺

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