Rimonabant

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发布时间： 2024-07-15 12:32:46

CAS号：168273-06-1

常用名： 利莫纳班

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Rimonabant(SR141716) is a selective central cannabinoid (CB1) receptor inverse agonist with Ki of 1.8 nM.IC50 Value: 1.8 nM(Ki)Target: CB1 Receptorin vitro: Rimonabant dose-dependently reduces ACAT activity in Raw264.7macrophages with IC50 of 2.9 μM and isolated peritoneal macrophages. Rimonabant inhibits ACATactivity in intact CHO-ACAT1 and CHO-ACAT2 cells and in cell-free assays with approximately equal efficiency with IC50 of 1.5 μM and 2.2 μM for CHO-ACAT1 and CHO-ACAT2, respectively. Consistent with ACAT inhibition, Rimonabant treatment blocks ACAT dependent processes in macrophages, oxysterol-induced apoptosis and acetylated-LDL induced foam cell formation. Rimonabant antagonizes the inhibitory effects of cannabinoid receptor agonists on both mouse vas deferens contractions and adenylyl cyclase activity in rat brain membranes in a concentration-dependent manner.in vivo: Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES (Regulated upon Activation, Normal T cell Expressed, and Secreted) and MCP-1 (monocyte chemotactic protein-1) serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant. Platelets from obese rats are more sensitive to thrombin-induced aggregation and adhesion to fibrinogen, which are both attenuated by Rimonabant therapy. 物理化学性质： CAS号：168273-06-1 常用中文名：利莫纳班常用英文名：Rimonabant 分子式：C22H21Cl3N4O 分子量：463.787 密度：1.4±0.1 g/cm3 沸点：627.6ºC at 760 mmHg 熔点：230-240ºC 闪点：333.3ºC 储存条件：2~8°C

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

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其他供应商价格：

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2025-09-17 价格：￥需询单 5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-N-(哌啶-1-基)-1H-吡唑-3-甲酰胺

2024-07-15 价格：需询单 Rimonabant

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2017-08-15 价格：￥需询单利莫那班

2020-12-10 价格：$需询单 Rimonabant

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2018-03-21 价格：￥需询单利莫那班

2022-05-12 价格：$需询单 Rimonabant

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利莫纳班价格

Rimonabant

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