地拉考昔

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发布时间： 2024-07-15 12:32:48

CAS号：169590-41-4

常用名： 地拉考昔

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID). IC50 Value: 70 to 150 uM(inhibition of 3 osteosarcoma cell lines) [1]Target: COXin vitro: Concentration of deracoxib required for 50% inhibition of cell viability (IC50) was reached in all 3 osteosarcoma cell lines and ranged from 70 to 150 microM, whereas the IC50 for piroxicam was only reached in the POS cell line at 500 microM. Neither deracoxib nor piroxicam induced sufficient toxicity in fibroblasts to reach an IC50. Exposure of osteosarcoma cells to cytotoxic concentrations of deracoxib and piroxicam did not result in DNA fragmentation [1]. Concomitant treatment of cells with piroxicam and deracoxib resulted in significant induction of apoptosis at lower concentrations and accumulation of cells in the G /G phase. Significant cytotoxic effects exhibited by the combination of piroxicam and deracoxib against canine mammary carcinoma cells in vitro suggest an attractive approach for the treatment of canine mammary carcinoma [2].in vivo: Perioperative administration of deracoxib to dogs at 1-2 mg/kg/day for 3 days significantly improves analgesia in the postoperative surgical period after soft tissue surgery [3]. Dogs were treated PO with deracoxib at a dosage of 3 mg/kg/d (1.36 mg/lb/d) as a single-agent treatment for TCC. Tumor response was assessed via radiography, abdominal ultrasonography, and ultrasonographic mapping of urinary bladder masses. Toxic effects of deracoxib administration in dogs were assessed through clinical observations and hematologic and biochemical analyses. 24 dogs for which tumor response was assessed, 4 (17%) had partial remission, 17 (71%) had stable disease, and 3 (13%) had progressive disease; initial response could not be assessed in 2 of 26 dogs. The median survival time was 323 days. Median time to progressive disease was 133 days. Renal, hepatic, and gastrointestinal abnormalities attributed to deracoxib administration were noted in 4% (1/26), 4% (1/26), and 19% (5/26) of dogs, respectively [4]. 物理化学性质： CAS号：169590-41-4 常用中文名：地拉考昔常用英文名：deracoxib 分子式：C17H14F3N3O3S 分子量：397.372 密度：1.5±0.1 g/cm3 沸点：575.5±60.0 °C at 760 mmHg 熔点：N/A 闪点：301.9±32.9 °C 储存条件：-20℃

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公司名：上海念兴实业有限公司推荐

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商品数： 403768件

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地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

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2024-07-15 价格：需询单地拉考昔

2019-03-05 价格：￥1166.0 地拉考昔

2022-11-29 价格：￥需询单 Deracoxib

2021-02-06 价格：￥9589.0 Deracoxib

2024-03-12 价格：￥41.9 地拉考昔

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