咪达那新

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发布时间： 2024-07-15 12:32:48

CAS号：170105-16-5

常用名： 咪达那新

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).IC50 value: 0.3 nM(M3) [1]in vitro: KRP-197 showed equipotent anti-M2 and anti-M3 activity and decreased subtype-selectivity [1]. in vivo: Intraduodenal administration of KRP-197 (0.04±0.30 mg/kg) inhibited bladder contraction dose-dependently, and the ED30 value was 0.11 mg/kg. The inhibitory action of KRP-197 on the bladder contraction was 19 times as potent as that of oxybutynin. KRP-197 showed preventive action againstthe decrease in bladder capacity induced by carbachol(ED50 0.074 mg/kg, intragastric administration), andthe potency of the inhibitory action was 15-fold greaterthan that of oxybutynin [1]. The learning-inhibitory doses of intravenous oxybutynin hydrochloride and tolterodine tartrate were 0.3 and 3 mg/kg in sham-operated rats and 0.1 and 1 mg/kg in nbM-lesioned rats, respectively. Thus, the learning impairments by those antimuscarinics were more sensitive in nbM-lesioned rats than in sham-operated rats. On the other hand, intravenous administration of imidafenacin had no influence on learning in either case of the rats. In normal rats, however, intracerebroventricular administration of imidafenacin impaired learning to the same degree as that of oxybutynin hydrochloride [2]. 物理化学性质： CAS号：170105-16-5 常用中文名：咪达那新常用英文名：Imidafenacin 分子式：C20H21N3O 分子量：319.400 密度：1.1±0.1 g/cm3 沸点：579.7±50.0 °C at 760 mmHg 熔点：N/A 闪点：304.4±30.1 °C 储存条件：2-8℃

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公司名：上海念兴实业有限公司推荐

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2024-03-12 价格：￥399.9 咪唑啉

2025-09-17 价格：￥需询单咪达那新

2017-06-12 价格：￥需询单咪达那新

2017-07-03 价格：￥需询单咪达那新

2017-12-08 价格：￥需询单咪达那新

2017-06-18 价格：￥需询单咪达那新杂质

2022-08-23 价格：￥需询单咪达非那辛

2019-06-14 价格：￥需询单咪达那新

2024-01-09 价格：$需询单 C20H21N3O Imidafenacin 170105-16-5

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咪达那新

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