Methylproamine

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发布时间： 2024-07-15 12:33:11

CAS号：188247-01-0

常用名： Methylproamine

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Methylproamine is a DNA-binding radioprotector which, on the basis of published pulse radiolysis studies, acts by repair of transient radiation-induced oxidative species on DNA.IC50 Value: N/ATarget: DNA-binding radioprotectorin vitro: The extent of radioprotection at the clonogenic survival endpoint increased with methylproamine concentration up to a maximum dose modification factor (DMF) of 2.0 at 10 μM. At least 0.1 fmole/nucleus of methylproamine is required to achieve a substantial level of radioprotection (DMF of 1.3) with maximum protection (DMF of 2.0) achieved at 0.23 fmole/nucleus. The γH2AX focus yield per cell nucleus 45 min after irradiation decreased with drug concentration with a DMF of 2.5 at 10 μM [1]. Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence ofmethylproamine decreased the amount of lower molecular weight DNA entering the gel as shown by the pulsed field gel electrophoresis assay [2]. Experiments with V79 cells have shown that methylproamine is approximately 100-fold more potent than the classical aminothiol radioprotector WR1065. The crystal structures of methylproamine and proamine complexes with the dodecamer d(CGCGAATTCGCG)(2) confirm that the new analogues also are minor groove binders [3].in vivo: N/AClinical trial: N/A 物理化学性质： CAS号：188247-01-0 常用中文名：Methylproamine 常用英文名：Methylproamine 分子式：C28H31N7 分子量：465.59300 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃

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2022-03-04 价格：￥1674.0 Methylproamine

2024-07-15 价格：需询单 Methylproamine

2022-09-23 价格：￥2667.0 Methylproamine

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