K-7174

产品详情：

发布时间： 2024-07-15 12:33:14

CAS号：191089-60-8

常用名： K-7174二盐酸盐

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.IC50 value:Target: GATA-specific inhibitorin vitro: K-7174 inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either tumor necrosis factor alpha or interleukin-1beta, without affecting the induction of intercellular adhesion molecule-1 or E-selectin. K-7174 had no effect on the stability of VCAM-1 mRNA.K-7174 did not influence the binding to any of the following binding motifs: octamer binding protein, AP-1, SP-1, ets, NFkappaB, or interferon regulatory factor [1]. Addition of 10 microM K-7174 rescued these inhibitions of Epo protein production and promoter activity induced by IL-1beta, TNF-alpha, or L-NMMA, respectively [2]. K-7174 had the potential to induce endoplasmic reticulum (ER) stress evidenced by induction of GRP78 and CHOP.Other inducers of ER stress completely reproduced the effects of K-7174 including suppression of lipid accumulation, blockade of induction of adiponection and PPARgamma and maintenance of MCP-1 expression [3].in vivo: K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib [4]. 物理化学性质： CAS号：191089-60-8 常用中文名：K-7174二盐酸盐常用英文名：K-7174 (dihydrochloride) 分子式：C33H50Cl2N2O6 分子量：641.67 密度：1.1±0.1 g/cm3 沸点：689.9±55.0 °C at 760 mmHg 熔点：N/A 闪点：171.2±28.7 °C 储存条件：2-8℃

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

联系人： 小陈

联系人电话： 0086-021-52280163

邮件：sales@echemcloud.com

网址：http://www.echemcloud.com

主要市场：

年贸易额：

外贸占销售比例：

主要合作伙伴：

公司介绍：

其他供应商价格：

2024-07-15 价格：需询单 K-7174

2022-11-29 价格：￥需询单 K-7174 dihydrochloride

2021-02-06 价格：￥1089.0 K-7174

2025-02-05 价格：￥6500.9 K-7174 dihydrochloride

查看所有价格请点击：

K-7174二盐酸盐价格

K-7174

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：