BRL-15572二盐酸盐

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发布时间： 2024-07-15 12:33:17

CAS号：193611-72-2

常用名： BRL15572 盐酸盐

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： BRL-15572 2Hcl is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. IC50 Value: 7.9(pKi)Target: 5-HT1D Receptorin vitro: BRL-15572 displays high affinity and selectivity for h5-HT1D receptors. BRL-15572 has 60-fold higher affinity for h5-HT1D than 5-HT1B receptors. BRL-15572 binds to h5-HT1B and h5-HT1D receptors with pKB of less than 6 and 7.1, respectively. BRL-15572 stimulates [35S]GTP γ S binding in both cell lines, with potencies that correlated with their receptor binding affinities in both h5-HT1B and h5-HT1D receptor expressing cell lines. BRL-15572 reveals receptor binding affinities for 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 with pKi of 7.7, 6.1, 5.2, 6.0, 6.6, 7.4, 6.2, 5.9 and 6.3, respectively. In the h5-HT1D cell line, both BRL-15572 (1 μM) shifts the 5-HT concentration response curve with pKB of 7.1, respectively. BRL-15572 does have moderately high affinity at human 5-HT1A and 5-HT2B receptors.in vivo: In diabetic pithed rats, administration of the selective 5-HT1D receptor antagonist BRL-15572 (2 mg/kg) does not modify the decreased HR induced by vagal electrical stimulation. The effects of L-694,247 (50 μg/kg), a selective agonist for non-rodent 5-HT1B and 5-HT1D receptors, on the vagally induced bradycardia are not apparent after pretreatment with BRL-15572. 物理化学性质： CAS号：193611-72-2 常用中文名：BRL15572 盐酸盐常用英文名：BRL-15572 分子式：C25H29Cl3N2O 分子量：479.87 密度：N/A 沸点：580.7ºC at 760 mmHg 熔点：N/A 闪点：305ºC 储存条件：Desiccate at +4°C

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2024-07-15 价格：需询单 BRL-15572二盐酸盐

2021-02-06 价格：￥614.0 BRL-15572

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BRL15572 盐酸盐价格

BRL-15572二盐酸盐

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