(R)-5-羟甲基托特罗定

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发布时间： 2024-07-15 12:33:31

CAS号：207679-81-0

常用名： (R)-5-羟甲基托特罗定

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纯度： 99.0%

备货期： 10天

库存： 现货

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用途： (R)-5-Hydroxymethyl Tolterodine(PNU-200577; Desfesoterodine) is a potent and selective muscarinic receptor antagonist with a Kb and a pA2 of 0.84 nM and 9.14, respectively. IC50 value: 0.84 nM (Kb)Target: mAChR(R)-5-Hydroxymethyl Tolterodine is a major pharmacologically active metabolite of tolterodine. In vitro, (R)-5-Hydroxymethyl Tolterodine prevented carbachol-induced contraction of guinea-pig isolated urinary bladder strips in a competitive and concentration-dependent manner. In vivo, (R)-5-Hydroxymethyl Tolterodine was significantly more potent at suppressing acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50=15 and 40 nmol/kg, respectively). In radioligand binding studies carried out in homogenates of guinea-pig tissues and Chinese hamster ovary cell lines expressing human muscarinic m1-m5 receptors, (R)-5-Hydroxymethyl Tolterodine was not selective for any muscarinic receptor subtype. Thus, (R)-5-Hydroxymethyl Tolterodine is similar to tolterodine in terms of antimuscarinic potency, functional selectivity for the urinary bladder in vivo and absence of selectivity for muscarinic receptor subtypes in vitro. The results of this study clearly indicate that (R)-5-Hydroxymethyl Tolterodine contributes to the therapeutic action of tolterodine, in view of its high antimuscarinic potency, similar serum concentration and lower degree of protein binding. 物理化学性质： CAS号：207679-81-0 常用中文名：(R)-5-羟甲基托特罗定常用英文名：5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) 分子式：C22H31NO2 分子量：341.487 密度：1.1±0.1 g/cm3 沸点：490.7±45.0 °C at 760 mmHg 熔点：68-72°C 闪点：233.2±27.4 °C 储存条件：-20?C Freezer

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其他供应商价格：

2022-03-04 价格：￥204.9 5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)

2025-09-17 价格：￥需询单 (R)-5-羟甲基托特罗定

2024-07-15 价格：需询单 (R)-5-羟甲基托特罗定

2018-04-05 价格：￥需询单 Fesoterodine fumarate Intermediate 2

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(R)-5-羟甲基托特罗定价格

(R)-5-羟甲基托特罗定

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