SB271046(Hydrochloride)

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发布时间： 2024-07-15 12:33:33

CAS号：209481-24-3

常用名： SB 271046盐酸盐

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纯度： 99.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： SB271046 Hcl is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.IC50 Value: 8.9(pKi)Target: 5-HT6 Receptorin vitro: SB 271046 hydrochloride is a sulfonamidal benzothiophene derivative that has been shown to act as a selective 5-HT6 antagonist with pKi values of 9.02-8.92, 6.55, 6.35, 6.27, 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and 200-fold selective over 55 other receptors, enzymes and ion channels.in vivo: SB-271046 is moderately brain penetrant (10%), subject to low blood clearance (7.7 mL/min/kg) with a good half-life in rats (4.8 hours), and has excellent oral bioavailability (>80%). SB-271046 produces 3-fold and 2-fold increases in extracellular glutamate levels in both frontal cortex and dorsal hippocampus of rats, respectively, which may be used for the treatment of cognitive and memory dysfunction. SB-271046 (20 mg/kg, orally gavage) 30 min prior to training Wistar rats, is found to reverse significantly the amnesia produced by administering scopolamine (0.8 mg/kg, i.p.) in the 6 hours post-training period. SB-271046 progressively and significantly decreases platform swim angle and escape latencies over the five sequential trials on four consecutive daily sessions compared to vehicle-treated controls in aged rats. SB-271046 also improves task recall as measured by significant increases in the searching of the target quadrant on post-training days 1 and 3. SB-271046 (10 mg/kg, s.c.) produces a significant, tetrodotoxin-dependent, increase in extracellular levels of both glutamate and aspartate within the frontal cortex of rats, reaching maximum values of 375.4% and 215.3% of preinjection values, respectively. 物理化学性质： CAS号：209481-24-3 常用中文名：SB 271046盐酸盐常用英文名：SB 271046 (Hydrochloride) 分子式：C20H23Cl2N3O3S2 分子量：488.45 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃

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公司名：上海念兴实业有限公司推荐

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2022-03-04 价格：￥875.9 SB 271046盐酸盐

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SB 271046盐酸盐价格

SB271046(Hydrochloride)

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